关键词: 血小板减少, 外周血淋巴细胞绝对值, 儿童

Abstract: Objective  To evaluate the clinical value of absolute lymphocyte count(ALC)  for chronic primary immune thrombocytopenia in children. Methods  The PubMed, Embase,  Cochrane Library,  CNKI, China Biology Medicine disc(CBMdisc), VIP and Wanfang digital knowledge service platform were searched for relevant literatures published in both English and Chinese. The search time was from the establishment of the database to February 2020. Two researchers independently extracted data and evaluated the included literature. Risk assessment  of literature bias was carried out. Meta Disc 1.4 software was used for meta analysis,  and the combined sensitivity,  specificity,  positive likelihood ratio,  negative likelihood ratio and the summary receiver operating characteristic（SROC）  curve were calculated. Results  A total of five studies with 1 301 children were included,  in which the combined sensitivity,  combined specificity,  combined positive likelihood ratio,  combined negative likelihood ratio and the area under the SROC curve (AUC) for the diagnosis of chronic primary immune thrombocytopenia in children were 0.70（95%CI［0.66，0.73］）, 0.65（95%CI［0.60，0.69］）, 3.36（95%CI［1.57，7.19］）, 0.45（95%CI［0.34，0.60］）  and  0.771, Q=0.711, respectively. Conclusion  Initial ALC has only moderate sensitivity and specificity for predicting the diagnosis of chronic ITP in children, and the clinical value of ALC for predicting the development of chronic ITP in children remains further study.

Key words: thrombocytopenia, absolute lymphocyte count, children