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哮喘儿童睡眠紊乱和注意缺陷多动障碍特征及相关性研究

  

  1. 广西壮族自治区人民医院 a.儿科;b.认知睡眠中心,广西 南宁 530021
  • 出版日期:2020-07-20 发布日期:2020-06-04
  • 通讯作者: 谢庆玲, Email: xieql9@163.com
  • 基金资助:
    广西自然科学基金项目----注意缺陷多动障碍哮喘儿童脑功能及相关影响因素的研究(桂科自 2013GXNSFAA019266);
    广西卫健委科研课题----哮喘儿童睡眠紊乱与注意力缺陷关系的临床研究(Z20170302)

Characteristics and correlation of sleep disorder and attention  deficit hyperactivity disorder in children with asthma

  1. a.Department of Pediatrics; b.Cognitive Sleep Center,  the People's Hospital of
    Guangxi Zhuang Autonomous Region, Nanning 530021, China
  • Online:2020-07-20 Published:2020-06-04
  • Contact: Corresponding author: Xie Qingling, Email: xieql9@163.com

摘要: 目的  探讨哮喘患儿睡眠障碍与注意缺陷多动障碍的特点及关联性。方法  选择6~14岁哮喘慢性持续期患儿35例,通过肺功能及哮喘控制测试评分(ACT)分为哮喘基本控制组和未控制组。对患儿进行儿童睡眠紊乱量表评分和夜间睡眠监测,并完成视听整合持续操作测试( IVACPT)和戴斯-纳格利尔里认知评估系统(DN:CAS)检测。结果  两组的儿童睡眠紊乱量表(SDSC)总粗分、入睡或维持睡眠障碍、睡眠-觉醒转换障碍、睡眠出汗过多指标比较差异有统计学意义(P<0.01)。夜间睡眠监测参数多项指标两组比较差异有统计学意义(P<0.05)。IVACPT检测哮喘未控制组综合反应控制力商数(FSCQ)、综合注意力商数(FSAQ)较哮喘基本控制组明显减低(P<0.01);DN:CAS参数指标中哮喘基本控制组和哮喘未控制组患儿的计划力(PLAN)、同时性加工能力(SIM)、注意力(ATT)、继时性加工能力(SUC)、认知水平得分(FS),比较均有统计学意义(P<0.05)。 IVACPT指标中FSCQ、FSAQ和DN: CAS中PLAN、SIM、ATT、SUC、FS 与睡眠参数中的SDSC总粗分 、入睡或维持障碍、睡眠-觉醒转换障碍、AHI呈负相关(均P<0.05),与睡眠效率、最低血氧呈正相关 (均P<0.05)。结论  哮喘患儿易出现睡眠结构紊乱和注意缺陷多动障碍,两者存在关联性影响。

关键词: 哮喘, 睡眠障碍, 注意力缺陷障碍伴多动, 儿童

Abstract: Objective   To explore the characteristics and correlation of sleep disorders and attention deficit hyperactivity disorder in children with asthma. Methods   Thirtyfive children aged 6 to 14 with chronic duration of asthma were selected and divided into asthma basic control group and asthma noncontrol group according to the lung function and asthma control test (ACT) scores. The children's sleep disorder scale was scored and their nighttime sleep monitoring was performed. The integrated visual and auditory continuous performance test(IVACPT) and DasNaglieri cognitive assessment system (DN:CAS) were completed. Results  There were significant differences in the indicators of  Sleep Disturbances Scale for Children(SDSC) total score, disorders of initiating or maintaining sleep, sleepwake transition disorders and excessive sleep sweating between two groups (P<0.01). There were significant differences in the night sleep monitoring parameters between  two groups (P<0.05). Full scale response control quotient(FSCQ) and full scale attention quotient(FSAQ) in asthma noncontrol group detected by IVACPT were significantly lower than those in basic control group (P<0.01). Among the DN: CAS parameters, there were significant differences in planning ability(PLAN), simultaneous processing ability(SIM), attention ability(ATT), successive processing ability(SUC) and full cognition score(FS) of children between two groups(P<0.05). FSCQ and FSAQ in IVACPT parameters and PLAN, SIM, ATT, SUC and FS in DN: CAS parameters were negatively correlated with SDSC total score, disorders of initiating or maintaining sleep, sleepwake transition disorders and AHI  in the sleep parameters(all P<0.05), and positively correlated with sleep efficiency and lowest blood oxygen value (all P<0.05). Conclusion  Children with asthma are prone to sleep structure disorder and attention deficit hyperactivity disorder,  which are related to each other.

Key words: asthma, sleep disorders, attention deficit with hyperactivity, children