临床荟萃 ›› 2021, Vol. 36 ›› Issue (7): 659-663.doi: 10.3969/j.issn.1004-583X.2021.07.018
应勤健1, 苗贤媛2, 崔晓颖3, 龙丹4, 付志璇4, 罗聪4(
)
收稿日期:2021-03-15
出版日期:2021-07-20
发布日期:2021-08-02
通讯作者:
罗聪
E-mail:lw939291@126.com
基金资助:
Received:2021-03-15
Online:2021-07-20
Published:2021-08-02
摘要：
巢蛋白(Nestin)是一种细胞骨架蛋白,多表达于肿瘤新生血管内皮细胞表面。通过干预肿瘤血管的形成,Nestin能够促进肿瘤细胞的增殖、侵袭和转移,介导肿瘤的发生发展,与肿瘤患者的预后密切相关,因此,Nestin可能成为一种全新的抗肿瘤治疗靶点。研究发现在多种恶性肿瘤,如神经胶质瘤、肺癌、乳腺癌及结肠癌中,Nestin的表达均显著升高。本文将围绕Nestin的结构、基本功能及其在常见肿瘤发生发展中发挥的作用进行综述,为临床相关研究提供新的思路。
中图分类号:
应勤健, 苗贤媛, 崔晓颖, 龙丹, 付志璇, 罗聪. 巢蛋白与肿瘤发生发展[J]. 临床荟萃, 2021, 36(7): 659-663.
图1 巢蛋白分子的结构 橙色:N端区域的“头”;蓝色:α螺旋杆区的中央杆部;绿色:C端区域的“尾”
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