溃疡性结肠炎患者血清吲哚胺2, 3-双加氧化酶水平及其与外周血CD4+的关系

doi:10.3969/j.issn.1004-583X.2021.08.004

临床荟萃 ›› 2021, Vol. 36 ›› Issue (8): 696-698.doi: 10.3969/j.issn.1004-583X.2021.08.004

溃疡性结肠炎患者血清吲哚胺2, 3-双加氧化酶水平及其与外周血CD4+的关系

张秀敏, 赵昌东, 李雪, 卢学峰, 刘维忠, 王淑芳()

南京医科大学康达学院附属连云港市第二人民医院消化内科,江苏连云港 222000

收稿日期:2021-01-25 出版日期:2021-08-20 发布日期:2021-08-30
通讯作者: 王淑芳 E-mail:changjinghan@126.com
基金资助:
2018年高层次卫生人才“六个一工程”拔尖人才项目——基于miRNA-214及其靶基因的调控探讨柠檬苦素治疗溃疡性结肠炎的作用机制(LGY2018061)

Relationship between indoleamine 2, 3-dioxygenase and peripheral blood CD4 + in patients with ulcerative colitis

Zhang Xiumin, Zhao Changdong, Li Xue, Lu Xuefeng, Liu Weizhong, Wang Shufang()

Department of Gastroenterology, the Second People's Hospital of Lianyungang Affiliated to Kangda College of Nanjing Medical University, Lianyungang 222000, China

Received:2021-01-25 Online:2021-08-20 Published:2021-08-30
Contact: Wang Shufang E-mail:changjinghan@126.com

摘要/Abstract

摘要：

目的探讨血清吲哚胺2, 3-双加氧化酶(IDO)在溃疡性结肠炎(UC)患者的表达及其与外周血CD4+的关系。方法收集2014年8月至2019年1月收治的72例溃疡性结肠炎(UC)患者进行回顾性分析,并将其作为观察组,另选同期体检的健康人群72例作为对照组。分别对组间及观察组不同疾病时期的血清IDO水平和外周血CD4+水平进行比较;分析观察组血清IDO水平和外周血CD4+表达水平的相关性。结果观察组血清IDO水平高于对照组,而外周血CD4+表达水平低于对照组(均P<0.05);观察组活动期血清IDO水平高于缓解期,而外周血CD4+表达水平低于缓解期(均P<0.05);观察组重度组及中度组外周血CD4+表达水平均低于轻度组,血清IDO水平均高于轻度组(均P<0.05);重度组外周血CD4+表达水平低于中度组,血清IDO水平高于轻度组(均P<0.05);Pearson相关性分析结果显示,UC患者血清IDO水平和外周血CD4+表达水平呈负相关(r=-0.801,P=0.000)。结论 UC患者血清IDO水平升高,外周血CD4+表达水平降低,且两者呈负相关。

关键词: 结肠炎,溃疡性, 血清IDO水平, CD4抗原

Abstract:

Objective To explore the relationship between indoleamine 2, 3-dioxygenase (IDO) and CD4 +in peripheral blood in patients with ulcerative colitis(UC).Methods Seventy-two patients with UC from August 2014 to January 2019 were retrospectively analyzed, and they were used as the observation group and 72 controls in the physical examination center during the same period were recruited. Aim to compare IDO and CD4+ between groups at different times and analyze the correlation between the two in the observation group.Results Compared with control group, IDO of patients in observation group was higher, while CD4+ was lower (all P<0.05). In observation group, the expression of IDO at active period was better than that at remission period, while CD4+ in peripheral blood of patients was lower than that at remission period (all P<0.05); CD4+ in peripheral blood of moderate-to-severe patients was lower than that of mild patients, which of severe patients was lower than that of moderate patients (all P<0.05); IDO of moderate-to-severe patients was higher than that of mild patients, which of severe patients was higher than that of mild patients (all P<0.05). Pearson correlation analysis showed that IDO was negatively correlated with CD4+ in peripheral blood in UC patients (r=-0.801, P=0.000).Conclusion The serum IDO level of UC patients increased, and the peripheral blood CD4+ expression level decreased, and they were negatively correlated.

Key words: colitis, ulcerative, serum IDO level, CD4 antigens

中图分类号:

R574.62

张秀敏, 赵昌东, 李雪, 卢学峰, 刘维忠, 王淑芳. 溃疡性结肠炎患者血清吲哚胺2, 3-双加氧化酶水平及其与外周血CD4+的关系[J]. 临床荟萃, 2021, 36(8): 696-698.

Zhang Xiumin, Zhao Changdong, Li Xue, Lu Xuefeng, Liu Weizhong, Wang Shufang. Relationship between indoleamine 2, 3-dioxygenase and peripheral blood CD4 + in patients with ulcerative colitis[J]. Clinical Focus, 2021, 36(8): 696-698.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.08.004

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I8/696

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参考文献 15

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组别	例数	IDO(U/L)	CD4+(%)
观察组	72	133.16±23.72	25.89±4.62
对照组	72	46.78±19.36	33.16±4.27
t值		23.939	9.806
P值		0.000	0.000

组别	例数	IDO(U/L)	CD4+(%)
观察组	72	133.16±23.72	25.89±4.62
对照组	72	46.78±19.36	33.16±4.27
t值		23.939	9.806
P值		0.000	0.000

组别	例数	IDO(U/L)	CD4+(%)
活动期	49	129.31±22.01	22.79±3.54
缓解期	23	104.37±18.76	28.76±2.98
t值		4.689	10.947
P值		0.000	0.000

组别	例数	IDO(U/L)	CD4+(%)
活动期	49	129.31±22.01	22.79±3.54
缓解期	23	104.37±18.76	28.76±2.98
t值		4.689	10.947
P值		0.000	0.000

组别	例数	IDO(U/L)	CD4+(%)
重度组	12	141.73±46.49^#*	18.76±3.67^#*
中度组	16	104.41±32.72^#	23.51±3.46^#
轻度组	21	73.59±17.02	26.49±3.01
F值		18.071	20.635
P值		0.000	0.000

溃疡性结肠炎患者血清吲哚胺2, 3-双加氧化酶水平及其与外周血CD4+的关系

Relationship between indoleamine 2, 3-dioxygenase and peripheral blood CD4 + in patients with ulcerative colitis

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