临床荟萃 ›› 2023, Vol. 38 ›› Issue (4): 319-323.doi: 10.3969/j.issn.1004-583X.2023.04.005

• 论著 • 上一篇    下一篇

辩证行为疗法联合舍曲林对伴有非自杀性自伤的青少年抑郁障碍患者的影响

段登艾1a, 邓燕1b, 张志雄1b, 谷樟林2()   

  1. 1.云南省精神病医院 a.女性精神医学科;b.精神康复二区,云南 昆明 650224
    2.云南省第三人民医院 心血管内科,云南 昆明 650011
  • 收稿日期:2023-02-17 出版日期:2023-04-20 发布日期:2023-06-06
  • 通讯作者: 谷樟林 E-mail:576888739@qq.com

Effect of dialectical behavior therapy combined with sertraline on adolescent depression disorder with non-suicidal self-injury

Duan Dengai1a, Deng Yan1b, Zhang Zhixiong1b, Gu Zhanglin2()   

  1. 1a. Department of Female Psychiatry; b. Second District of Mental Rehabilitation, Mental Hospital of Yunnan Province; Kunming 650224, China
    2. Department of Cardiovascular Medicine, the Third People's Hospital of Yunnan Province, Kunming 650011, China
  • Received:2023-02-17 Online:2023-04-20 Published:2023-06-06
  • Contact: Gu Zhanglin E-mail:576888739@qq.com

摘要:

目的 探索辩证行为疗法(dialectical behavior therapy, DBT)联合舍曲林对伴有非自杀性自伤(non-suicidal self-injury, NSSI)的青少年抑郁障碍患者疗效及应对方式的影响。方法 纳入2020年6月至2021年12月在云南省精神病医院诊断为伴有NSSI的青少年抑郁障碍的住院患者,按照入组先后顺序先分入联合组(35例),再分入对照组(35例),对照组服用舍曲林治疗,联合组在此基础上合并DBT干预。分别于基线(T0)、6周后(T1)、6月后(T2)使用汉密尔顿抑郁量表(Hamilton depression scale, HAMD)、青少年非自杀性自伤行为问卷、简易应对方式问卷(simplified coping style questionnaire)进行测量,并使用重复测量方差分析对观察指标进行分析。结果 T0时2组人口学资料、问卷评分差异均无统计学意义(P>0.05);2组T1、T2时自杀总分、HAMD、积极应对、消极应对评分存在组间差异(P<0.05),表现为联合组自杀总分、HAMD、消极应对分值降低更明显,积极应对分值提高更明显;2组自杀总分、HAMD、消极应对评分的差异存在时点×组别的交互作用。结论 给予伴有NSSI的青少年抑郁障碍患者提供DBT干预,能够降低HAMD分值,减少NSSI行为的发生,提高积极应对方式,摒弃消极应对方式,且持久性更好。

关键词: 抑郁障碍, 辩证行为疗法, 青少年, 非自杀性自伤, 应对方式

Abstract:

Objective To explore the effects of dialectical behavior therapy (DBT) combined with sertraline on the efficacy and coping styles of adolescent depression disorder with non-suicidal self-injury (NSSI). Methods From June 2020 to December 2021, patients with adolescent depressive disorder with NSSI who were hospitalized in Mental Hospital of Yunnan Province were enrolled in this study. According to the order of enrollment, the patients were divided into two groups, including: the combination group (35 cases) and the control group (35 cases). The control group received sertraline treatment, while the combination group received DBT and sertraline treatment. At baseline (T0), 6 weeks later (T1), and 6 months later (T2), the Hamilton Depression Scale (HAMD), Adolescent Non-suicidal Self-injury Assessment Questionnaire, Simplified Coping Style Questionnaire were used for measurement, and repeated measures analysis of variance was compared between the two groups. Results At T0, there was no significant difference in demographic data and questionnaire scores between the two groups (P>0.05). There were significant differences in total suicide score, HAMD, positive coping and negative coping scores between the two groups at T1 and T2 (P<0.05). The combination group showed a more significant decrease in total suicide score, HAMD and negative coping scores, whereas a more significant increase in positive coping score. The differences in total suicide score, HAMD and negative coping score between the two groups existed in the interaction of time point×group. Conclusion Providing DBT intervention to adolescent depression disorder patients with NSSI can lower HAMD score, reduce the occurrence of NSSI behavior, improve positive coping styles and discard negative coping styles, and have better durability.

Key words: depressive disorders, dialectical behavior therapy, adolescent, non-suicidal self-injury, coping styles

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