关键词: 高尿酸血症, 代谢疾病, 尿酸, 危险因素

Abstract: ObjectiveIn order to investigate the correlation between serum uric acid and metabolic syndrome (MS) and their risk factors. MethodsA total of 5 444 cases from Bai population， including urban， rural， urban fringe living for more than five years， were analyzed by questionnaire， physical examination and biochemical parameters. Results①With the level of uric acid elevated， the systolic blood pressure， diastolic blood pressure， triglycerides， lowdensity lipoproteins cholesterol， body mass index， waisthip ratio increased gradually in both men and women， however， highdensity lipoprotein protein cholesterol  decreased (P<0.01);  though fasting blood glucose and glycated hemoglobin in men showed no significant change with serum uric acid elevated (P>0.05)，but，the indexes increased gradually in women (P<0.01); ②The prevalence of hyperuricemia (HUA) and metabolic syndrome in men were higher than in women; with increasing age， the prevalence increased gradually（P<0.01）; the prevalence in urban， rural， urban fringe population increased gradually （P<0.01）. The smoking history， drinking history and family history of metabolic disease: the proportion in men was significantly higher than in women（P<0.01）; the proportion in urban， rural， urban fringe population increased gradually (P<0.01); with increasing age， the proportion of smoking history， alcohol consumption history decreased gradually (P<0.01); ③With the level of uric acid elevated， the prevalence of MS and its components increased gradually in both men and women (P<0.01) . ④Logistic regression analysis showed that  the level of serum uric acid was positively correlated with the prevalence of MS in both men and women， especially in women from Dali Bai population.ConclusionThe prevalence of HUA was high in Yunnan Dali Bai population， the level of serum uric acid was positively correlated with MS， and increasing uric acid was an independent risk factor of MS.

Key words: hyperuricemia, metabolic diseases, uric acid, risk factors