临床荟萃 ›› 2023, Vol. 38 ›› Issue (1): 37-41.doi: 10.3969/j.issn.1004-583X.2023.01.003

• 论著 • 上一篇    下一篇

唾液血液尿酸比与糖尿病周围神经病变的相关性

鞠岩1, 郭鹏3, 吴伯韬1, 刘新宇2()   

  1. 1.锦州医科大学 研究生院, 辽宁 锦州 121000
    2.锦州医科大学附属第一医院 内分泌科, 辽宁 锦州 121000
    3.辽阳市中心医院 心内科, 辽宁 辽阳 111000
  • 收稿日期:2022-07-24 出版日期:2023-01-20 发布日期:2023-03-03
  • 通讯作者: 刘新宇 E-mail:xxy-005@163.com
  • 基金资助:
    辽宁省自然基金指导计划——三七叶苷20(S)-25-OCH3-PPD对糖尿病大鼠心肌重塑的改善作用与机制(2019-ZD-0822);辽宁省教育厅自然科学项目——秦皮甲素通过调控EGFR-GSK-3β-CaMK通路对高血糖合并急性肺炎的治疗及机制研究(JYTJCZR2020064)

Correlation between ratio of salivary uric acid to blood uric acid and diabetic peripheral neuropathy

Ju Yan1, Guo Peng3, Wu Botao1, Liu Xinyu2()   

  1. 1. Graduate School,Jinzhou Medical University,Jinzhou 121000,China
    2. Department of Endocrinology, the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000,China
    3. Department of Cardiology,Liaoyang City Central Hospital,Liaoyang 111000,China
  • Received:2022-07-24 Online:2023-01-20 Published:2023-03-03
  • Contact: Liu Xinyu E-mail:xxy-005@163.com

摘要:

目的 探讨2型糖尿病(T2DM)中伴有糖尿病周围神经病变(diabetic peripheral neuropathy, DPN)患者血液尿酸(blood uric acid, BUA)和唾液尿酸(salivary uric acid, SUA)的动态变化, 并分析SUA/BUA与DPN的相关性及其预测价值。方法 选取2021年1月至2022年12月在我院内分泌科确诊的164例T2DM患者的临床资料, 根据临床症状及肌电图等辅助检查结果将所有患者分为DPN组(n=103)和单纯T2DM组(n=61)。检测并比较两组一般资料、SUA以及SUA/BUA情况;多因素Logistic回归分析DPN的相关影响因素;利用受试者工作特征(receiver operator characteristic curve,ROC)曲线评估相关影响因素的预测价值。结果 Logistic回归分析结果表明, 糖化血红蛋白( glycosylated hemoglobin,HbA1c)、SUA、SUA/BUA为DPN发生的危险因素。ROC曲线分析表明: HbA1c的AUC为0.637, 敏感度为50.8%, 特异度为78.6%, 最佳切点值为8.15。SUA的AUC为0.698, 敏感度为52.4%, 特异度为83.6%, 最佳切点值为388.43。BUA的AUC为0.762, 敏感度为86.4%, 特异度为73.8%, 最佳切点值为1.01。结论 SUA/BUA与DPN发病密切相关, 对诊断DPN有一定预测价值。

关键词: 糖尿病神经病变, 尿酸, 唾液, 血液

Abstract:

Objective To explore the dynamic change of blood uric acid (BUA) and salivary uric acid (SUA) in type 2 diabetes mellitus (T2DM) patients with diabetic peripheral neuropathy (DPN), and to study the correlation between ratio of SUA to BUA (SUA/BUA) and DPN, and its predictive value. Methods The clinic data of 164 T2DM patients in the Department of Endocrinology of our hospital from January 2021 to December 2022 was analyzed, and the patients were assigned to the DPN group (n=103) and the simple T2DM group (n=61) based on the clinical symptoms and electromyography results. The general data, SUA and SUA/BUA were compared. The DPN-related factors and their predictive value were respectively assessed by the multiple Logistic regression and receiver operator characteristic (ROC) curve. Results Logistic regression analysis showed that the risk factors of DPN were glycosylated hemoglobin (HbA1c), SUA, and SUA/BUA. ROC curve analysis showed that areas under curve (AUC), sensitivity, specificity, and optimal cut-off point of HbA1c were 0.637, 50.8%, 78.6%, and 8.15, respectively, those of SUA were 0.698, 52.4%, 83.6%, 388.43, respectively, and those of BUA were 0.762, 86.4%, 73.8%, 1.01, respectively. Conclusion SUA/BUA is closely associated with DPN, and with a certain predictive value in diagnosis of DPN.

Key words: diabetic neuropathies, uric acid, saliva, blood

中图分类号: