临床荟萃

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生血宁治疗维持性腹膜透析患者的临床观察

  

  1. 辽宁省人民医院 肾内科, 辽宁 沈阳 110016
  • 出版日期:2016-09-05 发布日期:2016-08-31
  • 通讯作者: 通信作者:赵霞,Email: iazhao@sina.com

Clinical observation on Shengxuening treating anemia in peritoneal dialysis patients

  1. Department of Nephrology, Liaoning Provincial People's Hospital, Shenyang 110016, China
  • Online:2016-09-05 Published:2016-08-31
  • Contact: Corrsponding author: Zhao Xia,Email: iazhao@sina.com

摘要: 目的比较生血宁片和多糖铁复合物胶囊(力蜚能)在治疗维持性腹膜透析患者肾性贫血中的治疗效果。方法选择维持性腹膜透析患者60例,随机分为力蜚能组和生血宁组,每组30例。分别于治疗前及治疗后每个月采血,检测患者血红蛋白、红细胞压积、C反应蛋白等指标。结果治疗前两组指标无明显差异,治疗3个月后两组患者的血红蛋白、红细胞压积指标均较治疗前显著上升,两组间无明显差异。两组基因重组人促红细胞生成素用量在治疗9个月后明显减少,两组间无明显差异。生血宁组发生消化道不良反应及引起血红蛋白过度升高的例数明显少于力蜚能组,差异有统计学意义。结论生血宁片同力蜚能一样能有效地纠正维持性腹膜透析患者的铁缺乏,降低患者基因重组人促红细胞生成素的用量;生血宁片比力蜚能胃肠道不良反应的发生概率更小,引起血红蛋白过度升高的发生概率更小。

关键词: 贫血, 缺铁性;腹膜透析, 持续不卧床;生血宁片;基因重组人促红细胞生成素

Abstract: ObjectiveTo compare the effect of Shengxuening tablet and capsule polysaccharideiron complex on anemia in peritoneal dialysis patients. MethodsA total of 60 peritoneal dialysis patients with anemia were randomly divided into Lifeineng group and Shengxuening tablet group. Hemoglobin, hematocrit, C reactive protein and other indicators were detected before treatment and each month after the treatment. ResultsBefore treatment, there was no significant difference between two groups. The levels of Hb and Hct were significantly increased after 3 month's treatment in both groups, however, there was no significant difference between two groups. After 9 month's treatment, the use of erythropoientin was significantly reduced in both groups, however, there was no significant difference between two groups. Shengxuening had significantly less adverse reaction of digestive tract and excessively rise of Hb than Lifeineng. ConclusionBoth oral iron and Shengxuening tablet can effectively improve the iron deficiency,anemia and reduce the use of erythropoientin in patients with peritoneal dialysis. Shengxuening has significantly less adverse reaction of digestive tract and excessively rise of Hb than Lifeineng.

Key words: anemia, irondeficiency, peritoneal dialysis, continuous ambulatory, recombinant human erythropoietin