老年冠心病患者并发低三碘甲状腺原氨酸综合征时冠状动脉病变特征分析

doi:10.3969/j.issn.1004-583X.2017.03.009

临床荟萃

老年冠心病患者并发低三碘甲状腺原氨酸综合征时冠状动脉病变特征分析

甘肃省康复中心医院老年病科，甘肃兰州 730000

出版日期:2017-03-05 发布日期:2017-03-06
通讯作者: 通信作者：杜绒贵，Email: 1731559180@qq.com

Association between serum triiodothyronine level and coronary artery disease in elderly patients with low triiodothvronine syndrome

Department of Geriatrics，the Rehabilitation Center Hospital of Gansu Province，Lanzhou 730000，China

Online:2017-03-05 Published:2017-03-06
Contact: Corresponding author: Du Ronggui，Email: 1731559180@qq.com

摘要/Abstract

摘要： 目的分析老年冠心病患者并发低三碘甲状腺原氨酸（T3）综合征时冠状动脉的病变特征，并探讨冠状动脉病变与T3水平的关系。方法选择确诊的275例老年冠心病并发低T3综合征患者为观察组，另选择275例老年冠心病无低T3综合征患者为对照组。检测两组的游离T3（FT3）、游离甲状腺素（FT4）及促甲状腺激素（TSH）水平，以冠状动脉病变的支数、Gensini评分对冠状动脉的病变程度进行评价，同时对冠状动脉病变与T3水平相关性进行分析。结果观察组的总胆固醇、低密度脂蛋白胆固醇较对照组升高（P<0.05）；观察组的FT3较对照组降低（P<0.05）；观察组的Gensini评分较对照组升高（P<0.05）；观察组冠状动脉3支血管病变、重度狭窄、完全闭塞的发生率均较对照组升高（均P<0.05）。经多因素Logistic回归分析提示低FT3水平是冠状动脉的病变数以及狭窄程度的一个预测因素。结论老年冠心病患者并发低T3综合征时主要以双支和多支冠状动脉的病变为主，且病变所累及的程度重、范围广。

关键词: 冠心病, 三碘甲状腺原氨酸, 甲状腺素

Abstract: ObjectiveTo investigate coronary artery lesion in elderly patients with coronary artery disease(CAD) combined with low three triiodothyronine(T3）syndrome，and the correlation between T3 serum hormone levels and coronary artery lesion. MethodsA total of 275 elderly CAD patients with low T3 syndrome served as group A，275 elderly CAD patients with normal free triiodothyronine（FT3），free thyroxine（FT4），thyroid stimulating hormone （TSH） were selected as group B（control group）. FT3，FT4 and TSH in two groups were determined. CAD was evaluated by lesion count and Gensini score was calculated according to the results of coronary arteriongraphy. ResultsTotal cholesterol and LDLC were higher in group A than in group B（P<0.05）.Serum FT3 in group A was lower than in group B（P<0.05）.Gensini score in group A was higher than in group B(P<0.05).As the characteristics of coronary artery lesion，three vessels disease incidence was higher in group A than in group B（P<0.05）.In group A，severe coronary artery stenosis and complete occlusion were higher compared with those in group B（P<0.05）.Multivariate logistic regression analysis showed that low FT3 was related to number and degree of coronary artery lesions. ConclusionThe lesion of CAD in the elderly patients with low T3 syndrome are mainly multivessel and twovessel lesion involving a wide range and higher severity.

Key words: coronary artery disease, triiodothyronine, thyroxine

杜绒贵. 老年冠心病患者并发低三碘甲状腺原氨酸综合征时冠状动脉病变特征分析[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2017.03.009.

Du Ronggui. Association between serum triiodothyronine level and coronary artery disease in elderly patients with low triiodothvronine syndrome[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2017.03.009.

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https://huicui.hebmu.edu.cn/CN/Y2017/V32/I3/216

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老年冠心病患者并发低三碘甲状腺原氨酸综合征时冠状动脉病变特征分析

Association between serum triiodothyronine level and coronary artery disease in elderly patients with low triiodothvronine syndrome

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