关键词: 血小板减少, 艾曲泊帕, meta分析

Abstract: Objective  To evaluate the shortterm efficacy,  bleeding improvement and safety of Ai Cooperpa in the treatment of adult idiopathic thrombocytopenic purpura(ITP). Methods  Randomized controlled study or single arm study of eltrombopag for the treatment of adult ITP were collected from Pubmed,  Wanfang database,  Vipu database,  CNKI,  Chinese biomedical literature database. The quality of the methodology used by the study was evaluated, the data was extracted, and  R software meta package was used to analyze the results.  Pubmed,  Wanfang Database,  Wipe Database,  CNKI,  and Chinese Biomedical Literature Database before April 2018 were retrieved for randomized controlled or singlearm studies of atropine in the treatment of adult ITP. After evaluating the methodological quality of the included studies and extracting the data,  R software meta package was used to merge and analyze the results. Results  Altogether, 5 randomized controlled trials and 2 single arm clinical trials were included,  including 633 adult ITP patients. The total effective rate of eltrombopag treatment was 68% and the rate of bleeding improved was 65%. Compared with the placebo group,  the total effective rate and the rate of bleeding improvement were significantly different,  and the adverse reaction was not statistically significant. Conclusion  Eltrombopag has definite curative effect and low adverse reaction on the treatment of adult ITP. It is a new choice for adult ITP treatment. 

Key words: thrombocytopenia, eltrombopag, meta analysis