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影响胃癌患者术后吻合口瘘的多因素分析

  

  1. 1.北京大学肿瘤医院暨北京市肿瘤防治研究所,恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142;
    2.佳木斯大学附属第一医院 麻醉科,黑龙江  佳木斯 154002
  • 出版日期:2019-12-20 发布日期:2020-01-19
  • 通讯作者: 谭宏宇,Email: maggitan@163.com

Multivariate analysis of postoperative anastomotic leakage in patients with gastric carcinoma

  1. 1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),
    Department of Anesthesiology,  Peking University Cancer Hospital & Institute,Beijing 100142,  China;
    2. Department of Anesthesiology, the First Affiliated Hospital of Jiamusi University,  Jiamusi 154007,China
  • Online:2019-12-20 Published:2020-01-19
  • Contact: Corresponding author: Tan Hongyu,Email:maggitan@163.com

摘要: 目的  探讨可能影响胃癌患者术后吻合口瘘发生的因素。方法  对2016年9月至2018年6月北京大学肿瘤医院行择期胃癌根治手术的499例患者病历资料回顾性研究。采用Logistic回归分析术后吻合口瘘的相关因素。结果  499例胃癌患者中,发生术后吻合口瘘23例(4.6%)。术后吻合口瘘相关因素有切除范围大(OR=2.633,P=0.045)、术中发生低血压(OR=4.617,P=0.007)、术后疼痛(OR=2.838,P=0.022)和饮酒史(OR=2.809, P=0.022)。结论  切除范围大、术中发生低血压、术后疼痛和饮酒史是术后吻合口瘘的危险因素。

关键词: 胃肿瘤, 吻合口瘘, 疼痛,  , 手术后, 危险因素

Abstract: Objective  To explore the influencing  factors  of postoperative anastomotic leakage in patients with gastric carcinoma.Methods  The clinical data of 499 patients that underwent elective radical gastrectomy  at Peking University Cancer Hospital from September 2016 to June 2018 were retrospectively reviewed. Logistic regression was used to analyze  the related factors of postoperative anastomotic leakage. Results  Among 499 patients with gastric carcinoma,  a total of 23 cases (4.6%) had postoperative anastomotic leakage. And the factors related to the postoperative anastomotic leakage included  large resection range (OR=2.633,  P=0.045),  intraoperative hypotension (OR=4.617,  P=0.007),  postoperative pain (OR=2.838,  P=0.022)  and drinking history (OR=2.809,  P=0.022).Conclusion  Large resection range,  intraoperative hypotension,  postoperative pain and drinking history were  risk factors for postoperative anastomotic leakage.

Key words: stomach , neoplasms;anastomotic leak; pain, , postoperative;risk , factors