营养状况对肺癌化疗患者所致恶心呕吐的影响

doi:10.3969/j.issn.1004-583X.2019.06.013

临床荟萃

营养状况对肺癌化疗患者所致恶心呕吐的影响

常州市第一人民医院营养科，江苏常州 213000

出版日期:2019-06-20 发布日期:2019-08-02
通讯作者: 陈璐，Email：chenluforever@163.com

Effect of nutritional status on nausea and vomiting caused by chemotherapy in patients with lung cancer

Department of Nutrition,The First People's Hospital of Changzhou, Changzhou 213000, China

Online:2019-06-20 Published:2019-08-02
Contact: Corresponding author：Chen Lu, Email: chenluforever@163.com

摘要/Abstract

摘要： 目的探讨营养状况对以顺铂为基础化疗的肺癌患者所致化疗相关性恶心呕吐（CINV）的影响。方法选取常州市第一人民医院采用顺铂化疗的肺癌住院患者200例，均选用昂丹司琼作为止吐药物，根据营养评定量表（PGSGA）评分分为营养不良组，无营养不良组，分析两组临床资料、营养相关指标、CINV。对存在营养不良的患者进行营养干预，比较营养干预前后CINV持续时间。结果纳入的200例患者中PGSGA评分≥4分122例，61%的患者存在营养不良。两组性别、年龄、肿瘤类型、肿瘤分期、化疗方案等临床资料差异均无统计学意义(P＞0.05）。多因素回归分析营养不良是CINV的独立危险因素。对存在营养不良的患者进行营养干预后，恶心呕吐持续时间较前改善（P＜0.01）。结论营养不良是CINV的独立危险因素，进行营养干预可改善CINV持续时间。

关键词: 肺肿瘤, 营养状况, 顺铂, 化疗相关性恶心呕吐

Abstract: Objective To investigate the effect of nutritional status on chemotherapyinduced nausea and vomiting by cisplatinbased chemotherapy in patients with lung cancer. Methods A total of 200 patients with lung cancer who received cisplatin chemotherapy in the First People's Hospital of Changzhou was selected, and ondansetron was used as antiemetic drug. All patients are divided into a malnutrition group and a nonmalnutrition group according to PGSGAscore, and the clinical data, nutritionrelated indicators, and CINV were analysed. Nutritional intervention was performed on malnourished patients, and the duration of CINV before and after nutritional intervention was compared. Results Among the 200 patients included, the PGSGA score was ≥4 points in 122 cases, which indicated that 61% of the 200 patients had malnutrition. There were no significant differences in clinical data between the two groups in terms of gender, age, tumor type, tumor stage, and chemotherapy regimen (P>0.05). Multivariate regression analysis showed that malnutrition was an independent risk factor for CINV(P<0.01). After nutritional intervention in patients with malnutrition, the duration of nausea and vomiting was improved (P<0.01). Conclusion Malnutritionisan is independent risk factor for CINV, and nutritional intervention can improve the duration of CINV.

Key words: lung neoplasms;nutritional status, cisplatin, chemotherapyinduced nausea and vomiting

仇怡，陈璐，瞿美娣，张敏，顾红柳，沙琦. 营养状况对肺癌化疗患者所致恶心呕吐的影响[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2019.06.013.

Qiu Yi, Chen Lu, Qu Meidi, Zhang Min, Gu Hongliu, Sha Qi. Effect of nutritional status on nausea and vomiting caused by chemotherapy in patients with lung cancer[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2019.06.013.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2019.06.013

https://huicui.hebmu.edu.cn/CN/Y2019/V34/I6/549

[1]	赵哲, 穆培娟, 张冬. 恩度联合顺铂胸腔灌注治疗肺癌合并恶性胸腔积液疗效的meta分析[J]. 临床荟萃, 2023, 38(5): 399-404.
[2]	张志萍, 张宝民, 秦伟, 高凌杰, 陈冬. 肠内营养支持对慢性阻塞性肺病急性加重期机械通气患者营养和预后的影响[J]. 临床荟萃, 2022, 37(6): 510-514.
[3]	黄平, 刘汉芸, 李玉红. 肺癌合并肺栓塞危险因素的Meta分析[J]. 临床荟萃, 2021, 36(12): 1061-1066.
[4]	李姮, 李永辉, 王琳, 何峰. 老年女性心力衰竭患者营养状况与预后相关分析[J]. 临床荟萃, 2021, 36(12): 1079-1082.
[5]	谭玲玲, 付泓博, 杨茗. 肌少症与肺癌患者预后相关性[J]. 临床荟萃, 2021, 36(12): 1132-1135.
[6]	陈星，张莉. 多西他赛、顺铂、5-氟尿嘧啶治疗晚期食管癌的meta分析[J]. 临床荟萃, 2020, 35(5): 389-395.
[7]	李双萍，毛毅敏，和雪改. 改良Wells评分对肺癌合并静脉血栓栓塞症的诊断价值[J]. 临床荟萃, 2020, 35(5): 421-424.
[8]	吕雅蕾1，宋丽娜2，单玉洁1，张晓琳3a，贾金海3b. 恩度联合顺铂对老年肿瘤患者恶性腹水的疗效[J]. 临床荟萃, 2020, 35(2): 162-165.
[9]	李百远1，李元军1, 2，高非凡1. 肺结核与肺癌相关性研究进展[J]. 临床荟萃, 2020, 35(10): 943-946.
[10]	赵宁1，梁文章1，侯彦2，马翠卿1. 肺泡巨噬细胞在肺癌中的研究现状[J]. 临床荟萃, 2019, 34(4): 377-384.
[11]	袁博云, 刘欣, 袁雅冬. 2018年呼吸系统疾病研究部分进展[J]. 临床荟萃, 2019, 34(1): 49-55.
[12]	陈本超，李恒，向旭东，李高峰，傅峰，郭琦，范胜亮，王德光. 埃克替尼联合放疗治疗肺癌脑转移疗效和安全性的Meta分析[J]. 临床荟萃, 2018, 33(8): 705-710.
[13]	袁博云，宫小薇，袁雅冬. 2017年呼吸疾病主要进展[J]. 临床荟萃, 2018, 33(1): 16-22.
[14]	蔡静静1，2，苗健龙1，周金花1，张影影1，2，刘瑞娟1. 慢性阻塞性肺疾病合并肺癌的临床特点分析[J]. 临床荟萃, 2017, 32(12): 1065-.
[15]	刘欣燕, 魏红艳, 戴献利, 刘颖. 经气管镜微创介入治疗中心型肺癌疗效分析[J]. 临床荟萃, 2016, 31(4): 389-391.

营养状况对肺癌化疗患者所致恶心呕吐的影响

Effect of nutritional status on nausea and vomiting caused by chemotherapy in patients with lung cancer

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价