关键词: 新型冠状病毒肺炎, 心肌型脂肪酸结合蛋白, 疾病严重程度

Abstract:

Objective To analyze the clinical characteristics of patients with mild & severe corona virus disease 2019 (COVID-19) and explore the correlation between herart fatty acid binding protein(H-FABP)and mild & severe COVID-19. Methods Totally 40 patients with negative expression of high-sensitivity troponin T (hs-cTnT) admitted to the Chongqing University Three Gorges Hospital before June 2022 were retrospectively analyzed. According to the diagnostic criteria of “Diagnosis and Treatment Protocol for COVID-19 (Trial Version 8)”, the patients were enrolled into the mild and severe groups. The expression levels of H-FABP in peripheral blood were compared between the two groups. Results Eligible 40 COVID-19 patients representing 20 cases in the mild group and 20 cases in the severe group were included. Compared with the mild group, the patients in the severe group were older ([41.9±10.5] vs [58.2±16.3]) years, and the proportion of patients with diabetes was higher (all P<0.05). H-FABP level in the severe group was significantly higher than that in the mild group ([3.97±1.80] vs [6.88±3.90] μg/L; [P<0.05], respectively). Conclusion In COVID-19 patients with negative hs-cTnT expression, serum H-FABP expression level is associated with the severity of COVID-19 disease. H-FABP may serve as a more sensitive and independent myocardial injury factor to contribute to the disease typing of COVID-19.

Key words: corona virus disease 2019, herart fatty acid binding protein, the severity of COVID-19 disease