多囊卵巢综合征患者血清S100A4水平变化及其对多囊卵巢综合征的影响

doi:10.3969/j.issn.1004-583X.2023.12.004

摘要/Abstract

摘要：

目的检测多囊卵巢综合征(polycystic ovary syndrome, PCOS)患者血清S100A4水平,探讨S100A4 对多囊卵巢综合征发生发展的影响。方法选取129例于2021年12月—2023年6月之间就诊于安徽医科大学第一附属医院内分泌科门诊,诊断为PCOS的育龄期患者为多囊卵巢综合征组(PCOS组),选取47名同期于安徽医科大学第一附属医院体检中心接受常规体检、月经规律正常并且无高雄激素血症(临床和生化)的健康育龄期女性为正常对照组(NC组)。根据BMI水平将PCOS组分为PCOS-超重组和PCOS-正常体重组;根据血糖水平将PCOS组分为PCOS-正常糖代谢组和PCOS-异常糖代谢组。收集两组临床资料,包括一般资料、S100A4水平及其他生化指标,比较两组临床资料的差异。结果 PCOS组血清S100A4水平高于NC组,差异有统计学意义( $P$ <0.01)。NC组、PCOS-正常组和PCOS-超重组间血清S100A4水平比较,差异有统计学意义( $P$ <0.01);其中PCOS-正常体重组和PCOS-超重组血清S100A4水平高于NC组,差异均有统计学意义( $P$ <0.05)。NC组、PCOS-正常糖代谢组和PCOS-异常糖代谢组血清S100A4水平比较,差异有统计学意义( $P$ <0.01);其中PCOS-正常糖代谢组和PCOS-异常糖代谢组血清S100A4水平高于NC组,差异均有统计学意义( $P$ <0.05)。Spearman相关分析结果显示,血清S100A4水平与HOMA-β呈负相关,与LDL-C呈正相关( $P$ <0.05)。多因素Logistic回归分析显示,S100A4是育龄期女性发生PCOS的影响因素[ $O R$ =1.046,95% $C I$ (1.015,1.078), $P$ <0.05]。ROC曲线:血清S100A4水平预测PCOS的曲线下面积为0.681( $P$ <0.01),其最佳截断值为0.176 ng/ml。结论 PCOS患者血清S100A4升高,并与肥胖、胰岛素抵抗及脂代谢异常有关,参与PCOS的发生发展。

关键词: 多囊卵巢综合征, S100A4, 胰岛素抵抗, 肥胖症, 代谢

Abstract:

Objective To detect serum S100A4 levels in patients with polycystic ovary syndrome (PCOS) and explore the effects of S100A4 on the development. Methods One hundred twenty-nine women of childbearing age with PCOS were enrolled into PCOS group from December 2021 to June 2023 at the Department of Endocrinology of the First Affiliated Hospital of Anhui Medical University, and 47 healthy women of childbearing age with regular menstrual cycles and no hyperandrogenemia, who underwent routine medical examinations at the hospital in the same period, were as the normal control group (NC group). According to the levels of body mass index (BMI) and glucose metabolism, the PCOS group was assigned into PCOS-over BIM group, PCOS-normal BIM group, PCOS-normal glucose metabolism group and PCOS-abnormal glucose metabolism group, respectively. The general data, S100A4 levels, and other biochemical indicators were collected, and the differences of clinical data between groups were compared. Results The serum S100A4 level of PCOS group was significantly higher than that of the NC group ( $P$ <0.01). There was a significant difference in serum S100A4 levels amongNC group, PCOS-normal BIM group and PCOS-over BIM group ( $P$ <0.01), which was significantly higher in the latter two groups than that of NC group ( $P$ <0.05). There was a significant difference in serum S100A4 levels among NC group, PCOS-normal glucose metabolism group and PCOS-abnormal glucose metabolism group( $P$ <0.01), which was significantly higher in the latter two groups than that of NC group ( $P$ <0.05). Spearman related analysis results showed that serum S100A4 levels were negative correlation with homeostasis model assessment- β (HOMA-β) and positively correlated with low-density lipoprotein cholesterol (LDL-C) ( $P$ <0.05). Multi-factor logistic regression analysis showed that S100A4 was the influencing factor for the occurrence of PCOS in women of childbearing age ( $O R$ =1.046, 95% $C I$ : 1.015-1.078, $P$ <0.05). The area under receiver operating characteristic (ROC) curve for serum S100A4 levels predicting PCOS was 0.681, and its optimal cutoff value was 0.176 ng/ml ( $P$ <0.01). Conclusion The increase in serum S100A4 in PCOS patients was related to obesity, insulin resistance, and abnormal lipid metabolism, and involving the development of PCOS.

Key words: polycystic ovary syndrome, S100A4, insulin resistance, obesity, metabolize

中图分类号:

R711.75

任玉梅, 章秋, 胡红琳. 多囊卵巢综合征患者血清S100A4水平变化及其对多囊卵巢综合征的影响[J]. 临床荟萃, 2023, 38(12): 1078-1085.

Ren Yumei, Zhang Qiu, Hu Honglin. Effect of serum s100A4 levels on polycystic ovary syndrome in patients with polycystic ovary syndrome[J]. Clinical Focus, 2023, 38(12): 1078-1085.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2023.12.004

https://huicui.hebmu.edu.cn/CN/Y2023/V38/I12/1078

图/表 8

表1 NC组与PCOS组一般资料比较[M(P25,P75)]

Tab. 1 Comparison of general data between NC-group and PCOS-group(M[P25,P75])

组别	例数		年龄(岁)	身高(cm)		体重(kg)		BMI(kg/m²)
NC组	47		25.00(24.00~25.00)	163.00(160.00~168.00)		56.00(52.00~63.00)		21.03(19.49~23.34)
PCOS组	129		24.00(20.00~29.00)	164.00(160.00~166.00)		68.00(54.00~80.00)		25.95(21.295~30.47)
$Z$ 值			-1.160	-0.034		-4.081		-4.494
$P$ 值			0.246	0.486		<0.01		<0.01
组别		腰围(cm)			臀围(cm)		腰臀比
NC组		72.00(69.00~78.00)			93.00(90.00~98.00)		0.78(0.74~0.81)
PCOS组		87.00(73.00~97.00)			102.00(94.00~110.00)		0.85(0.79~0.895)
$Z$ 值		-5.012			-4.295		-4.676
$P$ 值		<0.01			<0.01		<0.01

表1 NC组与PCOS组一般资料比较[M(P25,P75)]

Tab. 1 Comparison of general data between NC-group and PCOS-group(M[P25,P75])

组别	例数		年龄(岁)	身高(cm)		体重(kg)		BMI(kg/m²)
NC组	47		25.00(24.00~25.00)	163.00(160.00~168.00)		56.00(52.00~63.00)		21.03(19.49~23.34)
PCOS组	129		24.00(20.00~29.00)	164.00(160.00~166.00)		68.00(54.00~80.00)		25.95(21.295~30.47)
$Z$ 值			-1.160	-0.034		-4.081		-4.494
$P$ 值			0.246	0.486		<0.01		<0.01
组别		腰围(cm)			臀围(cm)		腰臀比
NC组		72.00(69.00~78.00)			93.00(90.00~98.00)		0.78(0.74~0.81)
PCOS组		87.00(73.00~97.00)			102.00(94.00~110.00)		0.85(0.79~0.895)
$Z$ 值		-5.012			-4.295		-4.676
$P$ 值		<0.01			<0.01		<0.01

表2 NC组与PCOS组生化指标比较[M(P25,P75)]

Tab. 2 Comparison of biochemical indicators between NC-group and PCOS-group(M[P25,P75])

组别	例数	FBG( mmol/L)			2hBG(mmol/L)		FINS(mU/L)		2hINS(mU/L)				FCP(μg/L)
NC组	47	4.69(4.10~5.08)			5.25(4.57~5.95)		8.03(6.09~12.04)		44.56(28.68~63.82)				1.61(1.18~1.91)
PCOS组	129	5.32(4.91~5.72)			7.28(5.84~8.78)		15.05(9.73~22.76)		141.08(66.41~249.68)				2.2(1.445~2.71)
$Z$ 值		-5.866			-6.431		-5.036		-6.691				-3.185
$P$ 值		<0.01			<0.01		<0.01		<0.01				0.01
组别	2hCP(μg/L)		HOMA-IR			HOMA-β				ISI		TG( mmol/L)
NC组	5.83(4.40~7.55)		1.66(1.20~2.58)			138.06(74.73~229.57)				0.03(0.02~0.04)		0.80(0.67~1.11)
PCOS组	8.72(6.87~12.40)		3.04(1.62~5.06)			131.61(82.95~230.73)				0.01(0.01~0.03)		1.17(0.93~1.68)
$Z$ 值	-5.565		-3.862			-0.202				-3.815		-4.772
$P$ 值	0.01		<0.01			0.84				<0.01		<0.01
组别	TC( mmol/L)			HDL-C( mmol/L)				LDL-C( mmol/L)			S100A4( ng/ml)
NC组	4.23(3.60~4.99)			1.3(1.09~1.53)				2.06(1.58~2.59)			0.14(0.12~0.16)
PCOS组	4.40(3.93~4.875)			1.26(1.10~1.46)				2.68(2.19~3.13)			0.17(0.13~0.23)
$Z$ 值	-0.757			-0.756				-3.948			-3.676
$P$ 值	0.449			0.450				<0.01			<0.01

表2 NC组与PCOS组生化指标比较[M(P25,P75)]

Tab. 2 Comparison of biochemical indicators between NC-group and PCOS-group(M[P25,P75])

组别	例数	FBG( mmol/L)			2hBG(mmol/L)		FINS(mU/L)		2hINS(mU/L)				FCP(μg/L)
NC组	47	4.69(4.10~5.08)			5.25(4.57~5.95)		8.03(6.09~12.04)		44.56(28.68~63.82)				1.61(1.18~1.91)
PCOS组	129	5.32(4.91~5.72)			7.28(5.84~8.78)		15.05(9.73~22.76)		141.08(66.41~249.68)				2.2(1.445~2.71)
$Z$ 值		-5.866			-6.431		-5.036		-6.691				-3.185
$P$ 值		<0.01			<0.01		<0.01		<0.01				0.01
组别	2hCP(μg/L)		HOMA-IR			HOMA-β				ISI		TG( mmol/L)
NC组	5.83(4.40~7.55)		1.66(1.20~2.58)			138.06(74.73~229.57)				0.03(0.02~0.04)		0.80(0.67~1.11)
PCOS组	8.72(6.87~12.40)		3.04(1.62~5.06)			131.61(82.95~230.73)				0.01(0.01~0.03)		1.17(0.93~1.68)
$Z$ 值	-5.565		-3.862			-0.202				-3.815		-4.772
$P$ 值	0.01		<0.01			0.84				<0.01		<0.01
组别	TC( mmol/L)			HDL-C( mmol/L)				LDL-C( mmol/L)			S100A4( ng/ml)
NC组	4.23(3.60~4.99)			1.3(1.09~1.53)				2.06(1.58~2.59)			0.14(0.12~0.16)
PCOS组	4.40(3.93~4.875)			1.26(1.10~1.46)				2.68(2.19~3.13)			0.17(0.13~0.23)
$Z$ 值	-0.757			-0.756				-3.948			-3.676
$P$ 值	0.449			0.450				<0.01			<0.01

表3 NC组、PCOS-超重组及PCOS-正常体重组胰岛素敏感性相关参数、糖脂代谢指标及S100A4水平比较[M(P25,P75)]

Tab. 3 Comparison of parameters of insulin sensitivity, glycolipid metabolic index and serum S100A4 levels among NC group, PCOS-normal BIM group and PCOS-over BIM group (M[P25,P75])

组别	例数			BMI(kg/m²)			FBG( mmol/L)			2hBG( mmol/L)		FINS(mU/L)	2hINS(mU/L)
NC组	47			21.03(19.49~23.34)			4.69(4.10~5.08)			5.25(4.57~5.95)		8.03(6.09~12.04)	44.56(28.68~63.82)
PCOS-正常体重组	56			20.93(18.96~22.13)^#			5.03(4.80~5.61)^*#			6.84(5.36~7.87)^*#		10.07(5.95~12.72)^#	95.79(44.00~173.72)^*#
PCOS-超重组	73			29.75(27.11~32.88)^*			5.48(5.03~5.98)^*			7.60(6.23~9.53)^*#		19.60(14.96~30.31)^*	179.55(90.48~260.57)^*
$H$ 值				120.850			43.352			48.252		71.007	56.660
$P$ 值				<0.01			<0.01			<0.01		<0.01	<0.01
组别		FCP(μg/L)			2hCP(μg/L)			HOMA-IR			HOMA-β				ISI
NC组		1.61(1.18~1.91)			5.83(4.40~7.55)			1.66(1.20~2.58)			198.33(140.46~294.28)				0.03(0.02~0.04)
PCOS-正常体重组		1.52(1.08~2.15)^#			7.64(5.46~10.035)^*#			2.36(1.35~3.50)^#			131.61(82.95~230.73)^#				0.02(0.01~0.03)^*
PCOS-超重组		2.52(2.08~3.38)^*			10.62(7.84~13.36)^*			4.76(3.67~7.2)^*			112.67(71.50~163.90)^*				0.01(0.01~0.01)^*
$H$ 值		44.565			44.381			74.707			28.080				74.774
$P$ 值		<0.01			<0.01			<0.01			<0.01				<0.01
组别			TG( mmol/L)			TC( mmol/L)			HDL-C( mmol/L)			LDL-C( mmol/L)		S100A4(ng/ml)
NC组			0.80(0.67~1.11)			4.23(3.60~4.99)			1.30(1.09~1.53)			2.06(1.58~2.59)		0.14(0.12~0.16)
PCOS-正常体重组			1.07(0.69~1.39)^*#			4.41(3.84~5.02)			1.40(1.20~1.76)^#			2.48(1.89~3.15)^#		0.15(0.13~0.23)^*
PCOS-超重组			1.31(1.02~1.87)^*			4.40(4.05~4.84)			1.18(1.01~1.35)^*			2.79(2.47~3.04)^*		0.17(0.14~0.25)^*
$H$ 值			31.976			0.634			22.474			18.208		14.331
$P$ 值			<0.01			0.728			<0.01			<0.01		<0.01

表3 NC组、PCOS-超重组及PCOS-正常体重组胰岛素敏感性相关参数、糖脂代谢指标及S100A4水平比较[M(P25,P75)]

Tab. 3 Comparison of parameters of insulin sensitivity, glycolipid metabolic index and serum S100A4 levels among NC group, PCOS-normal BIM group and PCOS-over BIM group (M[P25,P75])

组别	例数			BMI(kg/m²)			FBG( mmol/L)			2hBG( mmol/L)		FINS(mU/L)	2hINS(mU/L)
NC组	47			21.03(19.49~23.34)			4.69(4.10~5.08)			5.25(4.57~5.95)		8.03(6.09~12.04)	44.56(28.68~63.82)
PCOS-正常体重组	56			20.93(18.96~22.13)^#			5.03(4.80~5.61)^*#			6.84(5.36~7.87)^*#		10.07(5.95~12.72)^#	95.79(44.00~173.72)^*#
PCOS-超重组	73			29.75(27.11~32.88)^*			5.48(5.03~5.98)^*			7.60(6.23~9.53)^*#		19.60(14.96~30.31)^*	179.55(90.48~260.57)^*
$H$ 值				120.850			43.352			48.252		71.007	56.660
$P$ 值				<0.01			<0.01			<0.01		<0.01	<0.01
组别		FCP(μg/L)			2hCP(μg/L)			HOMA-IR			HOMA-β				ISI
NC组		1.61(1.18~1.91)			5.83(4.40~7.55)			1.66(1.20~2.58)			198.33(140.46~294.28)				0.03(0.02~0.04)
PCOS-正常体重组		1.52(1.08~2.15)^#			7.64(5.46~10.035)^*#			2.36(1.35~3.50)^#			131.61(82.95~230.73)^#				0.02(0.01~0.03)^*
PCOS-超重组		2.52(2.08~3.38)^*			10.62(7.84~13.36)^*			4.76(3.67~7.2)^*			112.67(71.50~163.90)^*				0.01(0.01~0.01)^*
$H$ 值		44.565			44.381			74.707			28.080				74.774
$P$ 值		<0.01			<0.01			<0.01			<0.01				<0.01
组别			TG( mmol/L)			TC( mmol/L)			HDL-C( mmol/L)			LDL-C( mmol/L)		S100A4(ng/ml)
NC组			0.80(0.67~1.11)			4.23(3.60~4.99)			1.30(1.09~1.53)			2.06(1.58~2.59)		0.14(0.12~0.16)
PCOS-正常体重组			1.07(0.69~1.39)^*#			4.41(3.84~5.02)			1.40(1.20~1.76)^#			2.48(1.89~3.15)^#		0.15(0.13~0.23)^*
PCOS-超重组			1.31(1.02~1.87)^*			4.40(4.05~4.84)			1.18(1.01~1.35)^*			2.79(2.47~3.04)^*		0.17(0.14~0.25)^*
$H$ 值			31.976			0.634			22.474			18.208		14.331
$P$ 值			<0.01			0.728			<0.01			<0.01		<0.01

表4 NC组、PCOS-正常糖代谢组及PCOS-异常糖代谢组胰岛素敏感性相关参数、糖脂代谢指标及S100A4水平比较[M(P25,P75)]

Tab. 4 Comparison of parameters of insulin sensitivity, glycolipid metabolic index and serum S100A4 levels among NC group, PCOS-normal glucose metabolism group and PCOS- abnormal glucose metabolism group(M[P25,P75])

组别	例数		BMI(kg/m²)			FBG(mmol/L)		2hBG(mmol/L)	FINS(mU/L)		2hINS(mU/L)
NC组	47		21.03(19.49~23.34)			4.69(4.10~5.08)		5.25(4.57~5.95)	8.03(6.09~12.04)		44.56(28.68~63.82)
PCOS-糖代谢正常组	64		23.57(19.85~29.70)^*			4.93(4.69~5.21)		6.39(5.06~7.26)^*	12.40(6.84~18.49)^*		84.09(44.50~196.71)^*
PCOS-糖代谢异常组	65		27.54(22.17~31.50)^*#			5.72(5.40~6.44)^*#		8.78(7.46~11.05)^*#	17.94(12.41~27.72)^*#		179.55(90.48~260.57)^*#
$H$ 值			25.663			85.801		82.375	39.533		57.089
$P$ 值			<0.01			<0.01		<0.01	<0.01		<0.01
组别		FCP(μg/L)		2hCP(μg/L)				HOMA-IR	HOMA-β				ISI
NC组		1.61(1.18~1.91)		5.83(4.40~7.55)				1.66(1.20~2.58)	176.07(95.49~252.56)				0.03(0.02~0.04)
PCOS-糖代谢正常组		1.73(1.08~2.33)		7.52(5.49~10.44)^*				2.65(1.63~4.23)^*	155.23(110.37~232.61)				0.02(0.01~0.03)^*
PCOS-糖代谢异常组		2.52(1.75~3.56)^*#		11.14(8.40~14.76)^*#				4.68(3.54~7.51)^*#	131.61(82.95~230.73)				0.01(0.01~0.01)^*#
$H$ 值		29.466		51.114				56.550	1.327				56.739
$P$ 值		<0.01		<0.01				<0.01	0.515				<0.01
组别		TG( mmol/L)			TC( mmol/L)		HDL-C( mmol/L)			LDL-C( mmol/L)		S100A4( ng/ml)
NC组		0.80(0.67~1.11)			4.23(3.60~4.99)		1.30(1.09~1.53)			2.06(1.58~2.59)		0.14(0.12~0.16)
PCOS-糖代谢正常组		1.10(0.84~1.41)^*			4.39(3.85~4.86)		1.36(1.17~1.50)			2.67(2.00~2.97)^*		0.15(0.13~0.22)^*
PCOS-糖代谢异常组		1.34(1.02~1.99)^*#			4.40(4.12~4.91)		1.18(1.01~1.40)^*#			2.81(2.39~3.19)^*		0.17(0.13~0.23)^*
$H$ 值		30.584			1.157		9.442			17.625		13.731
$P$ 值		<0.01			0.561		0.009			<0.01		<0.01

表4 NC组、PCOS-正常糖代谢组及PCOS-异常糖代谢组胰岛素敏感性相关参数、糖脂代谢指标及S100A4水平比较[M(P25,P75)]

组别	例数		BMI(kg/m²)			FBG(mmol/L)		2hBG(mmol/L)	FINS(mU/L)		2hINS(mU/L)
NC组	47		21.03(19.49~23.34)			4.69(4.10~5.08)		5.25(4.57~5.95)	8.03(6.09~12.04)		44.56(28.68~63.82)
PCOS-糖代谢正常组	64		23.57(19.85~29.70)^*			4.93(4.69~5.21)		6.39(5.06~7.26)^*	12.40(6.84~18.49)^*		84.09(44.50~196.71)^*
PCOS-糖代谢异常组	65		27.54(22.17~31.50)^*#			5.72(5.40~6.44)^*#		8.78(7.46~11.05)^*#	17.94(12.41~27.72)^*#		179.55(90.48~260.57)^*#
$H$ 值			25.663			85.801		82.375	39.533		57.089
$P$ 值			<0.01			<0.01		<0.01	<0.01		<0.01
组别		FCP(μg/L)		2hCP(μg/L)				HOMA-IR	HOMA-β				ISI
NC组		1.61(1.18~1.91)		5.83(4.40~7.55)				1.66(1.20~2.58)	176.07(95.49~252.56)				0.03(0.02~0.04)
PCOS-糖代谢正常组		1.73(1.08~2.33)		7.52(5.49~10.44)^*				2.65(1.63~4.23)^*	155.23(110.37~232.61)				0.02(0.01~0.03)^*
PCOS-糖代谢异常组		2.52(1.75~3.56)^*#		11.14(8.40~14.76)^*#				4.68(3.54~7.51)^*#	131.61(82.95~230.73)				0.01(0.01~0.01)^*#
$H$ 值		29.466		51.114				56.550	1.327				56.739
$P$ 值		<0.01		<0.01				<0.01	0.515				<0.01
组别		TG( mmol/L)			TC( mmol/L)		HDL-C( mmol/L)			LDL-C( mmol/L)		S100A4( ng/ml)
NC组		0.80(0.67~1.11)			4.23(3.60~4.99)		1.30(1.09~1.53)			2.06(1.58~2.59)		0.14(0.12~0.16)
PCOS-糖代谢正常组		1.10(0.84~1.41)^*			4.39(3.85~4.86)		1.36(1.17~1.50)			2.67(2.00~2.97)^*		0.15(0.13~0.22)^*
PCOS-糖代谢异常组		1.34(1.02~1.99)^*#			4.40(4.12~4.91)		1.18(1.01~1.40)^*#			2.81(2.39~3.19)^*		0.17(0.13~0.23)^*
$H$ 值		30.584			1.157		9.442			17.625		13.731
$P$ 值		<0.01			0.561		0.009			<0.01		<0.01

表5 血清S100A4水平与年龄、体质指数、腰臀比、胰岛素敏感性相关参数及糖脂代谢指标相关性分析( r值)

Tab. 5 Correlation analysis of serum S100A4 levels with age, BMI, WHR, insulin sensitivity and glycolipid metabolic index

项目	年龄 (岁)	BMI (kg/m²)	腰臀比	FBG (mmol/L)	2hBG (mmol/L)	FINS (mU/L)	2hINS (mU/L)	FCP (μg/L)
PCOS组	0.038	-0.137	0.091	0.064	0.120	-0.075	-0.023	0.003
项目	2hCP (μg/L)	HOMA-IR	HOMA-β	ISI	TG (mmol/L)	TC (mmol/L)	HDL-C ( mmol/L)	LDL-C (mmol/L)
PCOS组	0.047	-0.042	-0.190^*	0.090	0.046	-0.087	-0.034	0.190^*

表6 矫正前S100A4对PCOS影响的Logistic回归分析

Tab. 6 Logistic regression analysis of the influence of S100A4 on PCOS before correction

项目	β	SE	Wald χ²值	$P$ 值	$O R$ 值	95% $C I$
截距	-1.594	0.735	4.697	0.030	0.0203
S100A4水平(pg/ml)	0.016	0.005	11.161	0.001	1.017	(1.007,1.026)

表6 矫正前S100A4对PCOS影响的Logistic回归分析

Tab. 6 Logistic regression analysis of the influence of S100A4 on PCOS before correction

项目	β	SE	Wald χ²值	$P$ 值	$O R$ 值	95% $C I$
截距	-1.594	0.735	4.697	0.030	0.0203
S100A4水平(pg/ml)	0.016	0.005	11.161	0.001	1.017	(1.007,1.026)

表7 矫正后S100A4对PCOS影响的Logistic回归分析

Tab. 7 Logistic regression analysis of the influence of S100A4 on PCOS after correction

项目	β	SE	Wald χ²值	$P$ 值	$O R$ 值	95% $C I$
截距	-28.365	12.481	5.165	0.023	0.000
S100A4水平	0.045	0.015	8.578	0.003	1.046	(1.015,1.078)

表7 矫正后S100A4对PCOS影响的Logistic回归分析

Tab. 7 Logistic regression analysis of the influence of S100A4 on PCOS after correction

项目	β	SE	Wald χ²值	$P$ 值	$O R$ 值	95% $C I$
截距	-28.365	12.481	5.165	0.023	0.000
S100A4水平	0.045	0.015	8.578	0.003	1.046	(1.015,1.078)

图1 血清S100A4水平预测PCOS的受试者工作特征曲线

Fig. 1 ROC curves for serum S100A4 levels predicting PCOS

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