慢性阻塞性肺疾病表型的研究进展

doi:10.3969/j.issn.1004-583X.2023.04.017

摘要/Abstract

摘要：

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)为呼吸系统的常见病、多发病,具有极高的发病率和死亡率。目前COPD被认为是一种具有多种表型的异质性疾病。本文对不同类型COPD表型的研究进展和各表型的特点进行综述,以期临床医师充分认识不同表型COPD患者的临床特征差异,予以最优化治疗。

中图分类号:

R563.3

张莹, 涂平华, 吴展陵. 慢性阻塞性肺疾病表型的研究进展[J]. 临床荟萃, 2023, 38(4): 377-380.

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https://huicui.hebmu.edu.cn/CN/Y2023/V38/I4/377

参考文献 31

[1]	Global initiative for chronic obstructive lung disease. Global strategy for prevention, diagnosis, and management of COPD (2021 REPORT)[EB/OL]. https://goldcopdorg/2021-gold-reports/, 2021-11-17.
[2]	World Health Organization Burden of COPD. The top 10 causes of death[EB/OL]. https://wwwwhoint/zh/news-room/fact-sheets/detail/the-top-10-causes-of-death, 2021-11-17.
[3]	Miravitlles M, Calle M, Molina J, et al. Spanish COPD guidelines (GesEPOC): Pharmacological treatment of stable COPD[J]. Aten Primaria, 2012, 44(7):425-437. doi: 10.1016/j.aprim.2012.04.005 URL
[4]	Zbozinkova Z, Barczyk A, Tkacova R, et al. POPE study: Rationale and methodology of a study to phenotype patients with COPD in central and eastern Europe[J]. Int J Chron Obstruct Pulmon Dis, 2016, 11:611-622.
[5]	Miravitlles M, Soler-Cataluña JJ, Calle M, et al. Spanish guidelines for management of chronic obstructive pulmonary disease (GesEPOC) 2017. Pharmacological treatment of stable phase[J]. Arch Bronconeumol, 2017, 53(6):324-335. doi: 10.1016/j.arbres.2017.03.018 URL
[6]	Golpe R, Suárez-Valor M, Martín-Robles I, et al. Mortality in COPD patients according to clinical phenotypes[J]. Int J Chron Obstruct Pulmon Dis, 2018, 13:1433-1439. doi: 10.2147/COPD URL
[7]	姚锡娟, 马倩, 刘韩韩, 等. 慢性阻塞性肺疾病不同临床表型患病率及临床特征的Meta分析[J]. 重庆医学, 2021, 50(1):126-132.
[8]	黄宇婷, 刘翱. HRCT定量测量与慢性阻塞性肺疾病表型的关系[J]. 中华肺部疾病杂志(电子版), 2015, 8(2):251-253.
[9]	李辉安, 师美娟, 沈聪, 等. 基于体素的COPD早期诊断与CT肺功能定量评估[J]. 西安交通大学学报(医学版), 2019, 40(2):187-192.
[10]	Segal LN, Martinez FJ. Chronic obstructive pulmonary disease subpopulations and phenotyping[J]. J Allergy Clin Immunol, 2018, 141(6):1961-1971. doi: S0091-6749(18)30332-4 pmid: 29884286
[11]	Kirby M, Tanabe N, Tan WC, et al. Total airway count on computed tomography and the risk of chronic obstructive pulmonary disease progression. findings from a population-based study[J]. Am J Respir Crit Care Med, 2018, 197(1):56-65. doi: 10.1164/rccm.201704-0692OC URL
[12]	Fan L, Xia Y, Guan Y, et al. Characteristic features of pulmonary function test, CT volume analysis and MR perfusion imaging in COPD patients with different HRCT phenotypes[J]. Clin Respir J, 2014, 8(1):45-54. doi: 10.1111/crj.12033 pmid: 23711228
[13]	王述红, 何正光, 罗晓斌, 等. 慢性阻塞性肺疾病患者胸部高分辨率CT指标分型特征[J]. 现代医院, 2016, 16(4):514-517.
[14]	谭博. 慢性阻塞性肺疾病患者胸部HRCT表型的肺功能和血清生物标志物特征研究[D]. 太原: 山西医科大学, 2016.
[15]	Fletcher C, Peto R. The natural history of chronic airflow obstruction[J]. Br Med J, 1977, 1(6077):1645-1648.
[16]	Ji W, Lim MN, Bak SH, et al. Differences in chronic obstructive pulmonary disease phenotypes between non-smokers and smokers[J]. Clin Respir J, 2018, 12(2):666-673. doi: 10.1111/crj.12577 pmid: 27805311
[17]	Savran O, Ulrik CS. Early life insults as determinants of chronic obstructive pulmonary disease in adult life[J]. Int J Chron Obstruct Pulmon Dis, 2018, 13:683-693. doi: 10.2147/COPD URL
[18]	Cho J, Lee CH, Hwang SS, et al. Risk of acute exacerbations in chronic obstructive pulmonary disease associated with biomass smoke compared with tobacco smoke[J]. BMC Pulm Med, 2019, 19(1):68. doi: 10.1186/s12890-019-0833-7 pmid: 30902075
[19]	Zhao D, Zhou Y, Jiang C, et al. Small airway disease: A different phenotype of early stage COPD associated with biomass smoke exposure[J]. Respirology, 2018, 23(2):198-205. doi: 10.1111/resp.13176 pmid: 28906034
[20]	Adachi H, Derevnina L, Kamoun S. NLR singletons, pairs, and networks: Evolution, assembly, and regulation of the intracellular immunoreceptor circuitry of plants[J]. Curr Opin Plant Biol, 2019, 50:121-131. doi: S1369-5266(18)30154-7 pmid: 31154077
[21]	Mincham KT, Bruno N, Singanayagam A, et al. Our evolving view of neutrophils in defining the pathology of chronic lung disease[J]. Immunology, 2021, 164(4):701-721. doi: 10.1111/imm.13419 pmid: 34547115
[22]	Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease[J]. J Allergy Clin Immunol, 2016, 138(1):16-27. doi: 10.1016/j.jaci.2016.05.011 pmid: 27373322
[23]	Hughes MJ, Sapey E, Stockley R. Neutrophil phenotypes in chronic lung disease[J]. Expert Rev Respir Med, 2019, 13(10):951-967. doi: 10.1080/17476348.2019.1654377 URL
[24]	Negewo NA, McDonald VM, Baines KJ, et al. Peripheral blood eosinophils: A surrogate marker for airway eosinophilia in stable COPD[J]. Int J Chron Obstruct Pulmon Dis, 2016, 11:1495-1504. doi: 10.2147/COPD URL
[25]	Antus B, Barta I. Blood eosinophils and exhaled nitric oxide: Surrogate biomarkers of airway eosinophilia in stable COPD and exacerbation[J]. Biomedicines, 2022, 10(9):2128. doi: 10.3390/biomedicines10092128 URL
[26]	David B, Bafadhel M, Koenderman L, et al. Eosinophilic inflammation in COPD:From an inflammatory marker to a treatable trait[J]. Thorax, 2021, 76(2):188-195. doi: 10.1136/thoraxjnl-2020-215167 URL
[27]	Sivapalan P, Lapperre TS, Janner J, et al. Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): A multicentre, randomised, controlled, open-label, non-inferiority trial[J]. Lancet Respir Med, 2019, 7(8):699-709. doi: 10.1016/S2213-2600(19)30176-6 pmid: 31122894
[28]	王晓娟, 方向阳. 慢性阻塞性肺疾病全球倡议2019:慢性阻塞性肺疾病诊断、治疗与预防全球策略解读[J]. 中国全科医学, 2019, 22(18):2141-2149. doi: 10.12114/j.issn.1007-9572.2019.00.064
[29]	Martinez-Garcia MA, Faner R, Oscullo G, et al. Inhaled steroids, circulating eosinophils, chronic airway infection, and pneumonia risk in chronic obstructive pulmonary disease. A network analysis[J]. Am J Respir Crit Care Med, 2020, 201(9):1078-1085. doi: 10.1164/rccm.201908-1550OC URL
[30]	Jabarkhil A, Moberg M, Janner J, et al. Elevated blood eosinophils in acute COPD exacerbations: Better short- and long-term prognosis[J]. Eur Clin Respir J, 2020, 7(1):1757274. doi: 10.1080/20018525.2020.1757274 URL
[31]	Kandemir Y, Doˇgan NÖ, Yaka E, et al. Clinical characteristics of neutrophilic, eosinophilic and mixed-type exacerbation phenotypes of COPD[J]. Am J Emerg Med, 2021, 45:237-241. doi: 10.1016/j.ajem.2020.08.044 pmid: 33041140

慢性阻塞性肺疾病表型的研究进展

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