质膜膜泡关联蛋白的生物学功能研究进展

doi:10.3969/j.issn.1004-583X.2023.07.011

摘要/Abstract

摘要：

内皮细胞包含几个特殊的纳米级结构域,例如小窝、窗孔和跨内皮通道,它们可以调节信号传导和内皮通透性。窗孔覆盖着一层薄的纤维隔膜,该隔膜由聚集形成筛板的质膜膜泡关联蛋白(plasma membrane vesicle-associated proteins,PLVAP)组成。PLVAP蛋白已被证明是形成内皮细胞隔膜所必需的。PLVAP是一种内皮细胞特异性蛋白,形成气孔隔膜和窗孔隔膜,调节血管通透性、白细胞迁移和血管生成。小鼠PLVAP缺失会导致体内平衡紊乱而过早死亡。以往研究表明,PLVAP与多种疾病的发生均有关,其潜在的临床应用价值亟待进一步探索。本文就PLVAP的结构、功能、疾病发展及其治疗靶点的作用作一综述。

中图分类号:

郭文惠, 雷皓月, 潘友卓, 张琦. 质膜膜泡关联蛋白的生物学功能研究进展[J]. 临床荟萃, 2023, 38(7): 647-653.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2023.07.011

https://huicui.hebmu.edu.cn/CN/Y2023/V38/I7/647

图/表 4

参考文献 57

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疾病	PLVAP水平	可能的机制
癌症^{[34⇓⇓⇓⇓⇓⇓-41]}	升高	血管生成、通透性增加
急性脑缺血病^[43]	升高	血管生成、通透性增加
脂肪型肝炎^[44-45]	降低	窗孔调节、基底膜形成
蛋白丢失性肠病^[46]	突变	渗透性增加
糖尿病性视网膜病变^[51-52]	升高	血管生成、通透性增加

疾病	PLVAP水平	可能的机制
癌症^{[34⇓⇓⇓⇓⇓⇓-41]}	升高	血管生成、通透性增加
急性脑缺血病^[43]	升高	血管生成、通透性增加
脂肪型肝炎^[44-45]	降低	窗孔调节、基底膜形成
蛋白丢失性肠病^[46]	突变	渗透性增加
糖尿病性视网膜病变^[51-52]	升高	血管生成、通透性增加

疾病	手段	病理机制
肝癌^[53]	重组单克隆抗PLVAP Fab-TF	抗血管生成
胆管癌^[37]		增加内皮细胞血管生成
胰腺癌^[40]	shRAN PLVAP	抗血管生成
恶性胶质瘤^[36]		抗血管生成、免疫细胞的浸润
糖尿病视网膜病变^[54]	靶向VEGFA-PLVAP	抗血管生成、保护血视网膜屏障
肺部疾病^[55-56]	脂质纳米粒	维持血管完整性
病毒性脑炎^[57]	PLVAP基因沉默	控制日本脑炎病毒在神经元的繁殖

疾病	手段	病理机制
肝癌^[53]	重组单克隆抗PLVAP Fab-TF	抗血管生成
胆管癌^[37]		增加内皮细胞血管生成
胰腺癌^[40]	shRAN PLVAP	抗血管生成
恶性胶质瘤^[36]		抗血管生成、免疫细胞的浸润
糖尿病视网膜病变^[54]	靶向VEGFA-PLVAP	抗血管生成、保护血视网膜屏障
肺部疾病^[55-56]	脂质纳米粒	维持血管完整性
病毒性脑炎^[57]	PLVAP基因沉默	控制日本脑炎病毒在神经元的繁殖

质膜膜泡关联蛋白的生物学功能研究进展

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