关键词: 心肌病, 肥厚性；受体, 肾上腺素能β1；多态性, 单核苷酸

Abstract: ObjectiveTo investigate influence of polymorphisms of beta 1adrenergic receptor G1165C site and A145G site on the cardiac hypertrophy in hypertensive patients. MethodsThe study mcluded healthy subjects 115 cases from simultaneous body check，hypertension patients with cardiac hypertrophy 113 cases，and hypertension patients without cardiac hypertrophy 114 cases. The polymorphisms of G1165C site and A145G site of beta1adrenergic receptor were detected by means of polymerase chain reactionrestriction fragment length polymorphism(PCRRFLP). Results(1)There were significant  difference between the occurrence of 1165C beta1adrenergic receptor (78.5%) in hypertensive patients without cardiac hypertrophy and  in hypertensive patients with cardiac hypertrophy (89.8%). There was no significant difference between the occurrence of 145G beta1adrenergic receptor (16.7%) in hypertensive patients with no cardiac hypertrophyand in hypertensive patients with cardiac hypertrophy (16.8%). (2) There was significant difference between the left ventricular mass index of hypertensive patients with cardiac hypertrophy (123.78±5.12) g/m2 in 1165G beta1adrenergic receptor， and (154.16±47.82)  g/m2  in 1165C beta1adrenergic receptor (P<0.05). There was no statistical difference between the left ventricular mass index of hypertensive patients with cardiac hypertrophy. The left ventricular mass index of 145A beta1adrenergic receptor and 145G beta1adrenergic receptor were (150.85±46.88) g/m2 and (152.11±44.31)  g/m2，respectively.ConclusionPolymorphisms of G1165C beta1adrenergic receptor was involved in occurring cardiac hypertrophy and regulating degree of cardiac hypertrophy in hypertensive cardiac hypertrophy. There was no correlation between polymorphisms of A145G beta1adrenergic receptor and left ventricular hypertrophy in hypertensive patients.

Key words: cardiomyopathy, hypertrophic；receptors, adrenergic, beta1；polymorphism, single nucleotide