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冠心病患者经皮冠状动脉介入治疗1年后发生支架内再狭窄影响因素分析

  

  1. 1.兰州市中医院 急诊科,甘肃 兰州 730050;  2.兰州市第一人民医院 心血管科,甘肃 兰州 730050
  • 出版日期:2018-08-05 发布日期:2018-09-10
  • 通讯作者: 通信作者:王莉,Email:Wangli702007@126.com

Analysis of influencing factors of in stent restenosis after percutaneous coronary intervention in patients with coronary heart disease

  1. 1. Department of Emergency,Lanzhou Traditional Chinese Medicine Hospital, Lanzhou 730050, China; 
    2.Department of Cardiology, the First People's Hospital of Lanzhou, Lanzhou 730050, China
  • Online:2018-08-05 Published:2018-09-10
  • Contact: Correspondence Author: Wang Li, Email:Wangli702007@126.com

摘要: 目的 探讨冠心病患者经皮冠脉介入(percutaneous coronary intervention,  PCI) 治疗1年后发生再狭窄的影响因素。方法 2016年1月至2018年5月于兰州市第一人民医院心血管科复查的行PCI治疗术后1年发生再狭窄的冠心病患者54例,另选择同期复查未发生再狭窄患者30例作为对照,检测糖化血红蛋白(HbA1c)、肌红蛋白(Myo)、尿酸(UA)、同型半胱氨酸(Hcy)、总胆红素(TBIL)、γ谷氨酰转肽酶(GGT)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白A1(APOA1)、载脂蛋白B(APOB)、脂蛋白a[Lp(a)],进行心肌梗死溶栓危险(TIMI)评分;分析介入治疗1年后发生再狭窄的危险因素。结果  与无再狭窄组比较,再狭窄组UA及MYO明显增高,差异有统计学意义(P<0.05);logistic回归分析发现UA、TBIL及Myo增高是行PCI治疗的冠心病患者1年后发生再狭窄的独立危险因素,APOA增高是其保护因素。结论  UA、TBIL及Myo增高是行PCI治疗的冠心病患者1年后发生再狭窄的独立危险因素,APOA增高是其保护因素。

关键词: 冠心病, 血管成形术,  , 气囊,  , 冠状动脉, 支架内再狭窄

Abstract: Objective  To investigate the influence factors of in stent restenosis(ISR )after 1 year of percutaneous coronary intervention (PCI) in patients with coronary heart disease(CHD). Methods  A total of 54 CHDpatients  who had restenosis one year after PCI were enrolled in the cardiovascular department of Lanzhou First People's Hospitalfrom January 2017 to May 2018. Another 30 patients without restenosis were selected as control group.The glycated hemoglobin (HbAlc), myoglobin (Myo), uric acid (UA), homocysteine (Hcy), total bilirubin (TBIL), γglutamyltranspeptidase (GGT), triacyl Glycerin (TG), total cholesterol (TC), highdensity lipoprotein cholesterol (HDLC), lowdensity lipoprotein cholesterol (LDLC), apolipoprotein A1 (APOA1), apolipoprotein B (APOB), lipid Protein a[Lp(a)], a myocardial infarction thrombolysis risk (TIMI) score were estimated.Therisk factors for restenosis after 1 year of PCI were analyzed.Results  Compared with the no restenosis group, the UA and MYO in the restenosis group were significantly increased(P<0.05). The logistic regression analysis found that the increase of UA, TBIL and MYO were independent risk factors for restenosis in CHD patients after 1 year. APOA is a protective factor. Conclusion  The increase of UA, TBIL and MYO is an independent risk factor for restenosis after PCI in patients with coronary heart disease. The increase of APOA is the protective factor.

Key words: coronary disease;angioplasty, , balloon, , coronary;coronary restenosis