关键词: 基因, 多态性,  , 单核苷酸, 受体,  , 肾上腺素能&beta, 2, 高血压

Abstract: Objective   To investigate the relationship between β2adrenergic receptor (β2AR) gene polymorphism and hypertension and genetic characteristics of primary hypertension  in Zhuang population in Baise  district.Methods  This study consisted of 98 patients,  who had hypertension with a history of at  least two years,  and 109 healthy individuals came from the same ethnical  group. For all the participants,  their  general physical health was examined and the biochemical biomarkers of their  blood  before  breakfast were  tested  by the analytical instruments. Then,  DNA was analyzed using polymerase chain reaction（PCR） in order to identify the genotypes and  allele frequencies of  β2AR genes rs6879202 and rs2053044. Meanwhile, Logistic regression of SPSS 19.0 software  was implemented to explore the risk of hypertension  induced by the gene frequency  of sites with significant statistical  differences.Results  There were significant differences in sex ratio,  creatinine,  smoking rate,  triglyceride and uric acid between case group and control group. For  β2ARrs6879202  gene locus: CC, CG, GG between  two groups,  the frequencies were 3.10%, 72.40%, 24.50%; 13.80%, 57.80%, 28.40%, respectively; the genotype  frequency distributions between two groups were statistically different (χ2=8.809,  P=0.012). The results of  Logistic  analysis showed that for  rs6879202, CG  was  associated with a higher risk of hypertension than the frequency of the other two genes.Conclusion   There was correlation between  β2AR gene rs6879202 locus polymorphism and primary hypertension in Zhuang ethical population in Baise region, while there was no correlation between  β2AR  gene rs2053044 locus polymorphism and primary hypertension in this region and nationality.

Key words: gene; , polymorphism, single nucleotide, receptors, adrenergic, beta2; , hypertension