冠心病患者外周血血小板分布宽度和红细胞分布宽度与心房颤动的患病风险

doi:10.3969/j.issn.1004-583X.2020.11.005

临床荟萃 ›› 2020, Vol. 35 ›› Issue (11): 984-987.doi: 10.3969/j.issn.1004-583X.2020.11.005

冠心病患者外周血血小板分布宽度和红细胞分布宽度与心房颤动的患病风险

承德医学院附属医院，承德市心血管病研究所 a.心脏内科；b.超声科, 河北承德 067000

出版日期:2020-11-20 发布日期:2020-10-21
通讯作者: 孙王乐贤，Email: lixiansun01@126.com

Correlation of platelet distribution width and red blood cell distribution width in peripheral blood with atrial fibrillation in patients with coronary artery disease

a.Department of Cardiology; b.Department of Ultrasonics, Affiliated Hospital of Chengde Medical University,
Chengde Institute of Cardiovascular Disease, Chengde 067000, China

Online:2020-11-20 Published:2020-10-21
Contact: Corresponding author: Sun Lixian, Email: lixiansun01@126.com

摘要/Abstract

摘要： 目的探讨冠心病（CAD）患者外周血血小板分布宽度（PDW）、红细胞分布宽度（RDW）与心房颤动（AF）的关系。方法连续入选2012 年1 月至2013 年12 月于承德医学院附属医院住院诊断为CAD合并AF患者149 例（病例组），在同期入院患CAD未合并AF患者中采用随机抽取149例（对照组）。通过诊断试验及拟合二元logistic多因素回归模型分别评价CAD患者PDW、RDW对AF的辅助诊断和预测价值。结果 CAD患者PDW、RDW诊断AF的受试者工作特征曲线下面积（ROCAUC）分别为0.612（95%CI 0.5840.616），0.684（95%CI 0.6240.744）（P均＜0.001）。PDW的最佳诊断界值13.5%, 敏感性、特异性、阳性预测值与阴性预测值分别为0.426、0.770、0.653、0.575；RDW的最佳诊断界值亦为13.5%，敏感性、特异性、阳性预测值与阴性预测值分别为0.631、0.651、0.646、0.642。Logistic回归分析显示： PDW＞13.5%，RDW≥13.5%均为CAD合并AF的新独立危险因素（均P＜0.05）。结论外周血PDW、RDW升高是CAD患者发生AF的独立危险因素，有望成为CAD患者预测发生AF较为新颖、可靠的临床实验室生物标志物。

关键词: 血小板, 红细胞, , 异常, 冠状动脉疾病, 心房颤动

Abstract: Objective To explore the correlation of platelet distribution width (PDW) and red blood cell distribution width (RDW) with atrial fibrillation (AF) in patients with coronary artery disease (CAD).Methods A total of 149 patients with CAD and AF in the Affiliated Hospital of Chengde Medical University from January 2012 to December 2013 were selected as case group. During the same period of admission, 149 patients with CAD but without AF were selected as the control group. The auxiliary diagnosis and prediction value of PDW and RDW for AF in CAD patients were respectively analyzed through diagnostic tests and binary logistic multiple factors regression model. Results The area under the curve(AUC) of the PDW and RDW for AF in CAD patients was 0.612(95%CI 0.5840.616) and 0.684(95%CI 0.6240.744), respectively (both P＜0.01). The optimal diagnostic threshold of PDW was 13.5%, and the sensitivity, specificity, positive predictive value and negative predictive value were 0.426, 0.770, 0.653 and 0.575, respectively. The optimal diagnostic threshold of RDW was also 13.5%, and the sensitivity, specificity, positive predictive value and negative predictive value were 0.631, 0.651, 0.646 and 0.642, respectively. Logistic regression analysis showed that PDW>13.5% and RDW≥13.5% were new independent risk factors for CAD combined with AF (both P<0.05). Conclusion The elevation of PDW and RDW in peripheral blood is an independent risk factor for AF in CAD patients, and it is expected to be a novel and reliable clinical laboratory biomarker for AF prediction in CAD patients.

Key words: blood platelets, erythrocytes, , abnormal, coronary disease, atrial fibrillation

中图分类号:

R541.4

高秀鑫a, 司月乔a, 丁振江a, 张英a, 刘会玲b, 刘静怡a, 韩超a, 孙王乐贤a. 冠心病患者外周血血小板分布宽度和红细胞分布宽度与心房颤动的患病风险[J]. 临床荟萃, 2020, 35(11): 984-987.

Gao Xiuxina, Si Yueqiaoa, Ding Zhenjianga, Zhang Yinga, Liu Huilinga, Liu Jingyia, Han Chaoa, Sunwang Lexianaa. Correlation of platelet distribution width and red blood cell distribution width in peripheral blood with atrial fibrillation in patients with coronary artery disease[J]. Clinical Focus, 2020, 35(11): 984-987.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2020.11.005

https://huicui.hebmu.edu.cn/CN/Y2020/V35/I11/984

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冠心病患者外周血血小板分布宽度和红细胞分布宽度与心房颤动的患病风险

Correlation of platelet distribution width and red blood cell distribution width in peripheral blood with atrial fibrillation in patients with coronary artery disease

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