降脂利肝颗粒联合辛伐他汀治疗NAFLD对肝生化指标、瘦素及脂联素的影响

doi:10.3969/j.issn.1004-583X.2021.01.012

摘要/Abstract

摘要：

目的探讨降脂利肝颗粒联合辛伐他汀治疗非酒精性脂肪肝(non-alcoholic fatty liver disease, NAFLD)对肝生化指标、瘦素及脂联素的影响。方法我院收治的94例NAFLD患者,随机分为对照组和观察组各47例。对照组行辛伐他汀治疗,观察组在此基础上联合降脂利肝颗粒治疗。分析两组术后疗效,并记录两组治疗前后的血脂、肝生化、瘦素(LP)、脂联素 (ADPN)等指标水平。结果治疗3个月后,观察组总有效治疗率为91.49%(43/47),显著高于对照组的72.34%(34/47)(P<0.05)。两组TG、TC、LDL-C、ALT、AST、GGT、LP水平均显著下降,HDL-C、ADPN水平显著升高,且观察组的改变程度显著高于对照组(P<0.05)。结论降脂利肝颗粒联合辛伐他汀可显著改善 NAFLD患者的血脂代谢和肝功能代谢平衡,有效调节机体内分泌、免疫、胰岛素功能。

关键词: 脂肪肝, 植物药疗法, 辛伐他汀, 实验室技术和方法

Abstract:

Objective To investigate the effect of Jiangzhi Ligan Granules combined with simvastatin on hepatic biochemical indexes, leptin and adiponectin in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods A total of 94 NAFLD patients admitted to our hospital were randomly divided into control group and observation group, with 47 cases in each group. Patients in control group were treated with simvastatin, and those in observation group were treated with Jiangzhi Ligan Granules more. The postoperative efficacy of two groups was analyzed, and the levels of blood lipids, liver biochemistry, leptin (LP), adiponectin (ADPN) and other indicators of two groups were recorded before and after treatment. Results After three months of treatment, the total efficacy rate of patients in observation group was 91.49% (43/47), which was significantly higher than 72.34% (34/47) in control group(P<0.05). TG, TC, LDL-C, ALT, AST, GGT and LP levels in both groups were significantly decreased, while HDL-C and ADPN levels were significantly increased, and the change degree in observation group was significantly higher than that in control group(P<0.05). Conclusion Jiangzhi Ligan Granule combined with simvastatin can significantly improve the balance of blood lipid metabolism and liver function metabolism in NAFLD patients,and effectively regulate the secretion, immunity and insulin functions of the body.

Key words: fatty liver, phytotherapy, simvastatin, laboratory techniques and procedures

中图分类号:

R575.5

张莹, 王春生. 降脂利肝颗粒联合辛伐他汀治疗NAFLD对肝生化指标、瘦素及脂联素的影响[J]. 临床荟萃, 2021, 36(1): 58-61.

Zhang Ying, Wang Chunsheng. Effects of Jiangzhi Ligan Granules combined with simvastatin on hepatic biochemical indexes, leptin and adiponectin in treatment of NAFLD[J]. Clinical Focus, 2021, 36(1): 58-61.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.01.012

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I1/58

图/表 4

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组别	例数	痊愈	有效	无效	总有效
对照组	47	15(31.91)	19(40.43)	13(27.66)	34(72.34)
观察组	47	21(44.68)	22(46.81)	4(8.51)	43(91.49)
Z值		1.621	0.389	5.817	5.817
P值		0.203	0.533	0.016	0.016

组别	例数	痊愈	有效	无效	总有效
对照组	47	15(31.91)	19(40.43)	13(27.66)	34(72.34)
观察组	47	21(44.68)	22(46.81)	4(8.51)	43(91.49)
Z值		1.621	0.389	5.817	5.817
P值		0.203	0.533	0.016	0.016

组别	例数	TG(mmol/L)		TC(mmol/L)		LDL-C(mmol/L)		HDL-C(mmol/L)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	47	2.64±0.59	1.98±0.46^*	6.31±0.84	5.33±0.60^*	4.28±0.69	3.19±0.58^*	1.09±0.33	1.29±0.39
观察组	47	2.69±0.60	1.76±0.33^*	6.2±0.78	4.83±0.52^*	4.34±0.74	2.86±0.54^*	1.11±0.31	1.56±0.41^*
t值		0.407	2.664	0.658	4.317	0.407	2.855	0.303	3.271
P值		0.685	0.009	0.512	0.000	0.685	0.005	0.763	0.002

组别	例数	TG(mmol/L)		TC(mmol/L)		LDL-C(mmol/L)		HDL-C(mmol/L)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	47	2.64±0.59	1.98±0.46^*	6.31±0.84	5.33±0.60^*	4.28±0.69	3.19±0.58^*	1.09±0.33	1.29±0.39
观察组	47	2.69±0.60	1.76±0.33^*	6.2±0.78	4.83±0.52^*	4.34±0.74	2.86±0.54^*	1.11±0.31	1.56±0.41^*
t值		0.407	2.664	0.658	4.317	0.407	2.855	0.303	3.271
P值		0.685	0.009	0.512	0.000	0.685	0.005	0.763	0.002

组别	例数	ALT(U/L)		AST(U/L)		GGT(U/L)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	47	95.35±17.75	61.47±15.19^*	88.62±17.25	58.77±14.06^*	103.5±24.29	74.43±18.14^*
观察组	47	96.24±18.52	53.63±13.61^*	88.16±17.36	51.91±12.57^*	103±23.61	62.93±16.28^*
t值		0.238	2.635	0.129	2.494	0.101	3.235
P值		0.813	0.010	0.898	0.014	0.920	0.002