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男性非酒精性脂肪性肝病相关危险因素及人体成分分析的应用价值

  

  1. 扬州大学附属医院 临床营养科,江苏 扬州 225000
  • 出版日期:2017-10-05 发布日期:2017-10-10
  • 通讯作者: 通信作者:包云,Email:baoy62@sina.com

Risk factors of nonalcoholic fatty liver disease in males and  value of  body composition analysis

  1. Department of Clinical Nutrition,  the Affiliated Hospital of Yangzhou University,   Yangzhou  225000,   China
  • Online:2017-10-05 Published:2017-10-10
  • Contact: Corresponding author: Bao Yun, Email:baoy62@sina.com

摘要: 目的 分析男性非酒精性脂肪性肝病(NAFLD)的危险因素并探讨人体成分分析在评估NAFLD严重程度的应用价值。方法 纳入诊断为NAFLD的男性体检者260例,根据超声分为轻度161例,中度65例,重度34例;无NAFLD的健康成年男性158例为对照组。采用人体成分分析仪检测人体成分,收集血清检测血脂、肝肾功能等指标。结果 4组体重、体重指数(BMI)、腹围、腰臀比、颈围、体脂百分比、内脏脂肪区域(VFA)、谷氨酰转肽酶(GGT)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)差异具有统计学意义;与对照组比较,中、重度NAFLD患者的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、空腹血糖(FBG)、尿酸(UA)差异有统计学意义;NAFLD的严重程度与体重、BMI、腹围、腰臀比、颈围、体脂百分比、VFA、ALT、GGT、TG、FBG、UA呈正相关,与HDLC呈负相关;NAFLD的高危因素是高FBG及高TG。结论 人体成分分析能够较准确地反映男性NAFLD的严重程度,FBG、TG增高是男性NAFLD发生的危险因素。

关键词: 脂肪肝, 身体成分, 危险因素

Abstract: Objective  To analyze the risk factors of nonalcoholic fatty liver disease (NAFLD) in males and discuss the value of the body composition analysis for evaluating the severity of NAFLD. Methods   A total of 260 male patients diagnosed as NAFLD were  included in the physical examination. According to the diagnosis of ultrasonography, 161 cases were divided into mild group, 65 cases in moderate group, and 34 cases in severe group.In addition,158 healthy male adults without NAFLD served as controls.The changes of body composition were analyzed by  body composition analyzer.Serum was collected to  measure serum lipid,liver and kidney function,ect.Results  Body weight, body mass index (BMI), abdominal perimeter, waist hip ratio, neck circumference, body fat percentage, visceral fat area (VFA), gamma glutamyl transpeptidase (GGT), triglyceride (TG) and high density lipoprotein cholesterol (HDLC) were significantly different between the four groups. Alanine transaminase (ALT), glutamic oxaloacetic transaminase (AST), fasting blood glucose (FBG) and uric acid (UA) of moderate and severe NAFLD patients were significantly higher than those  in control group.  The severity of NAFLD  was  positively correlated to body weight, BMI, abdominal perimeter, waist hip ratio, neck circumference, body fat percentage, VFA, ALT, GGT, TG, FBG and UA. Significant negative correlation was found between the severity of NAFLD and the level of HDLC. FBG and TG were the risk factors of NAFLD. Conclusion  Body composition analysis has a high value in the evaluation of NAFLD.  The risk factors of NAFLD in men were FBG and TG.

Key words: fatty liver;body composition, risk factors