PTX3在系统性硬化症患者血清中含量及血管病变中的意义

doi:10.3969/j.issn.1004-583X.2021.04.011

摘要/Abstract

摘要：

目的探讨血清正五聚蛋白3(PTX3)水平在评估系统性硬化症(SSc)患者疾病活动及血管病变中的意义。方法选取37例初治SSc患者为病例组,健康体检者31例为对照组。病例组分为疾病活动组和非活动组,肢端溃疡(DU)组和无DU组,肺动脉高压(PAH)组和无PAH组。分析各组间血清PTX3、成纤维细胞生长因子2(FGF2)水平及与改良Rodnan皮肤评分(mRss)、甲襞微循环检测总积分(NCTS)等的相关性。结果病例组血清PTX3水平高于对照组(P<0.05),且疾病活动组PTX3水平高于非活动组和对照组。DU组及PAH组PTX3、PTX3/FGF2水平均高于阴性对照组(P<0.05)。PTX3水平与NCTS、总胆固醇(CHOL)、低密度脂蛋白胆固醇(LDL-G)均呈正相关(P<0.05)。PTX3/FGF2水平升高是SSc患者合并PAH的危险因素(P<0.05)。结论 SSc患者血清PTX3水平在疾病活动判断方面有一定临床意义。PTX3/FGF2可能是SSc患者合并PAH的危险因素。

关键词: 硬皮病, 系统性, 正五聚蛋白3, 成纤维细胞生长因子2, 血管病变

Abstract:

Objective To explore the significance of level of pentraxin 3 (PTX3) in the serum for evaluating the disease activities of patients with systemic sclerosis (SSc) and vasculopathy. Methods Thirty seven patients with SSc receiving initial therapy were selected and divided into the case group, and 31 healthy subjects were selected and divided into the control group, the case group was further divided into the disease active group and inactive group, duodenal ulcer (DU) group and non-DU group, pulmonary hypertension (PAH) group and non-PAH group, aiming to analyze the correlation between the levels of serum PTX3 , fibroblast growth factor 2(FGF2) and modified Rodnan skin scores (mRss), nailfold microcirculation test total score (NCTS) in groups. Results The level of serum PTX3 in SSc group were significantly higher than that in the control group(P<0.05),and the level off PTX3 in disease active group was higher than that in the inactive group and the control group. The levels of PTX3 and PTX3/FGF2 in DU and PAH groups were higher than those in the negative control group(P<0.05).The level of PTX3 was positively associated with NCTS, total cholesterol (CHOL) and low density lipoprotein cholesterin(LDL-G)(P<0.05). Elevated level of PTX3/FGF2 was risk factor of patients with SSc accompanying with PAH(P<0.05). Conclusion Serum PTX3 level in patients with SSc delivers certain clinical significance in determine disease activity .PTX3/FGF2 may be risk factor for patients with SSc accompanying with PAH.

Key words: scleroderma, systemic, pentraxin 3, fibroblast growth factor 2, vasculopathy

中图分类号:

R953.25

李红艳, 汪晓平, 杨林, 何晶晶, 刘爱京. PTX3在系统性硬化症患者血清中含量及血管病变中的意义[J]. 临床荟萃, 2021, 36(4): 344-347.

Li Hongyan, Wang Xiaoping, Yang Lin, He Jingjing, Liu Aijing. Content of PTX3 in the serum of patients with systemic sclerosis and corresponding significance in vasculopathy[J]. Clinical Focus, 2021, 36(4): 344-347.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.04.011

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I4/344

图/表 7

参考文献 20

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组别	例数	PTX3(ng/ml)	FGF2(pg/ml)
对照组	31	2.43(1.58)	6.17(5.23)
病例组	37	4.77(2.04)	10.77(5.07)
Z值		-4.747	-3.103
P值		0.000	0.002

组别	例数	PTX3(ng/ml)	FGF2(pg/ml)
对照组	31	2.43(1.58)	6.17(5.23)
病例组	37	4.77(2.04)	10.77(5.07)
Z值		-4.747	-3.103
P值		0.000	0.002

组别	例数	PTX3(ng/ml)	FGF2(pg/ml)
对照组	31	2.43(1.58)	6.17(5.23)
非活动组	11	3.89(2.64)^#	6.39(8.48)
疾病活动组	26	4.97(2.81)^*	10.99(4.09)^*
F值		48.354	13.237
P值		0.000	0.001

组别	例数	PTX3(ng/ml)	FGF2(pg/ml)
对照组	31	2.43(1.58)	6.17(5.23)
非活动组	11	3.89(2.64)^#	6.39(8.48)
疾病活动组	26	4.97(2.81)^*	10.99(4.09)^*
F值		48.354	13.237
P值		0.000	0.001

组别	例数	PTX3 (ng/ml)	FGF2 (pg/ml)	PTX3/FGF2
DU组	7	6.99(2.36)	11.78±6.72	723.36(435.54)
无DU组	30	4.11(2.04)	10.28±4.03	392.78(104.20)
统计值		-3.451	0.776	-3.063
P值		0.001	0.443	0.002