康艾注射液联合贝伐珠单抗注射液和DP方案对非小细胞肺癌疗效及血清肿瘤标志物、预后的影响

doi:10.3969/j.issn.1004-583X.2021.06.007

摘要/Abstract

摘要：

目的观察康艾注射液联合贝伐珠单抗和DP方案治疗非小细胞肺癌(NSCLC)疗效及血清肿瘤标志物、预后的影响。方法回顾性选取2017年10月至2020年10月我院收治的95例NSCLC患者作为研究对象;以治疗方式分为3组,单纯DP治疗(对照组)30例,康艾注射液联合DP治疗(观察组一)34例,康艾注射液与贝伐珠单抗联合DP治疗(观察组二)31例。比较近期疗效、血清生化因子[血管内皮生长因子(VEGF)、糖类抗原19-9(CA199)、癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)]、生活质量[肺癌生存质量评价量表(FACT-L)]及生存时间。结果 3组近期疗效差异有统计学意义(P<0.05),且观察组一、观察组二的有效率均显著高于对照组(P<0.05)。3组治疗后血清VEGF、CA199、CEA、CYFRA21-1水平均显著下降(P<0.05);且治疗后血清VEGF、CA199、CEA、CYFRA21-1均以对照组>观察组一>观察组二(P<0.05)。3组FACT-L评分T1下降至最低(P<0.05)。T1、T2时点均以观察组二>观察组一>对照组(P<0.05)。观察组二生存时间显著高于对照组、观察组一(P<0.05)。结论康艾注射液及贝伐珠单抗联合DP化疗方案治疗NSCLC,能提升临床有效率、改善生活质量,并延长生存时间。

关键词: 癌, 非小细胞肺, 康艾注射液, 贝伐珠单抗, 生活质量, 生存时间

Abstract:

Objective To observe the efficacy of Kangai injection combined with bevacizumab and docetaxel plus cisplatin (DP scheme) on efficacy and serum tumor markers and prognosis of non-small cell lung cancer(NSCLC). Methods Totally 95 NSCLC patients admitted to our hospital from October 2017 to October 2020 were retrospectively selected as the research objects. According to the treatment methods, the patients were divided into three groups: 30 patients were treated with DP alone (control group), 34 patients were treated with Kangai injection combined with DP (observation group 1), and 31 patients were treated with Kangai injection combined with bevacizumab and DP scheme (observation group 2). Short-term efficacy, serum biochemical factors (VEGF, CA199, CEA, CYFRA21-1), quality of life (FACT-L) and survival time were compared. Results Short-term efficacy in three groups was significantly different (P<0.05), and effective rate in observation group 1 and group 2 was significantly higher than that in control group (P<0.05). After treatment, levels of serum VEGF, CA199, CEA and CYFRA21-1 in three groups were significantly decreased (P<0.05), the order from high to low: control group> observation group 1> observation group 2 (P<0.05). FACT-L score T1 in the three groups decreased to the lowest (P<0.05). At T1 and T2, the order FACT-L scores from high to low: observation group 2 > observation group 1 >control group (P<0.05). Survival time of cases in the observation group 2 was the highest in the three groups (P<0.05). Conclusion In the treatment of NSCLC, Kangai injection combined with bevacizumab and DP scheme can enhance the clinical effective rate, improve the quality of life and prolong the survival time.

Key words: carcinoma, non-small cell lung, kangai injection, bevacizumab, quality of life, survival time

中图分类号:

R734.2

王爱. 康艾注射液联合贝伐珠单抗注射液和DP方案对非小细胞肺癌疗效及血清肿瘤标志物、预后的影响[J]. 临床荟萃, 2021, 36(6): 517-521.

Wang Ai. Effects of Kangai injection combined with bevacizumab and DP scheme on efficacy and serum tumor markers and prognosis of NSCLC[J]. Clinical Focus, 2021, 36(6): 517-521.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2021.06.007

https://huicui.hebmu.edu.cn/CN/Y2021/V36/I6/517

图/表 4

参考文献 13

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组别	例数	CR	PR	SD	PD	有效率(%)
对照组	30	7(23.33)	6(20.00)	12(40.00)	6(20.00)	43.33(13/30)
观察组一	34	11(32.35)	13(38.24)	7(20.59)	3(8.82)	70.59(24/34)^*
观察组二	31	10(32.26)	15(48.39)*	4(12.90)	2(6.45)	80.65(25/31)^*
H/χ²值		6.478				8.249
P值		0.039				0.004

组别	例数	CR	PR	SD	PD	有效率(%)
对照组	30	7(23.33)	6(20.00)	12(40.00)	6(20.00)	43.33(13/30)
观察组一	34	11(32.35)	13(38.24)	7(20.59)	3(8.82)	70.59(24/34)^*
观察组二	31	10(32.26)	15(48.39)*	4(12.90)	2(6.45)	80.65(25/31)^*
H/χ²值		6.478				8.249
P值		0.039				0.004

组别	例数	VEGF(mg/L)		CA199(U/ml)		CEA(μg/L)		CYFRA21-1(ng/ml)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	30	221.08±43.35	173.64±31.32^※	87.24±13.34	45.27±8.36^※	110.78±21.85	49.84±8.81^※	14.71±3.31	7.18±1.37^※
观察组一	34	226.88±42.11	143.93±27.35^※*	86.75±14.04	39.63±6.7^※*	106.62±23.06	38.86±6.67^※*	15.12±3.28	5.53±1.10^※*
观察组二	31	220.5±42.52	103.32±20.04^※*△	89.74±12.34	27.66±4.28^※*△	109.79±22.76	30.87±4.56^※*△	14.39±3.42	3.02±0.88^※*△
组间		F=10.878, P<0.01		F=5.386, P<0.01		F=4.575, P<0.05		F=10.725, P<0.01
时点间		F=466.562, P<0.01		F=2127.230, P<0.01		F=1159.593, P<0.01		F=903.779, P<0.01
组间·时点间		F=26.813, P<0.01		F=29.744, P<0.01		F=6.448, P<0.01		F=11.904, P<0.01

组别	例数	VEGF(mg/L)		CA199(U/ml)		CEA(μg/L)		CYFRA21-1(ng/ml)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	30	221.08±43.35	173.64±31.32^※	87.24±13.34	45.27±8.36^※	110.78±21.85	49.84±8.81^※	14.71±3.31	7.18±1.37^※
观察组一	34	226.88±42.11	143.93±27.35^※*	86.75±14.04	39.63±6.7^※*	106.62±23.06	38.86±6.67^※*	15.12±3.28	5.53±1.10^※*
观察组二	31	220.5±42.52	103.32±20.04^※*△	89.74±12.34	27.66±4.28^※*△	109.79±22.76	30.87±4.56^※*△	14.39±3.42	3.02±0.88^※*△
组间		F=10.878, P<0.01		F=5.386, P<0.01		F=4.575, P<0.05		F=10.725, P<0.01
时点间		F=466.562, P<0.01		F=2127.230, P<0.01		F=1159.593, P<0.01		F=903.779, P<0.01
组间·时点间		F=26.813, P<0.01		F=29.744, P<0.01		F=6.448, P<0.01		F=11.904, P<0.01

组别	例数	T0	T1	T2
对照组	30	135.23±21.30	101.37±16.54^※	124.16±18.93^※#
观察组一	34	135.75±21.20	113.72±18.63^※*	144.23±20.48^※#*
观察组二	31	136.13±21.33	121.54±18.84^※*△	152.23±20.81^※#*△
组间		F=7.537,P<0.01
时点间		F=6.501,P<0.05
组间·时点间		F=17.947,P<0.01