青岛地区儿童幽门螺杆菌感染调查分析

doi:10.3969/j.issn.1004-583X.2022.02.009

摘要/Abstract

摘要：

目的了解青岛地区儿童幽门螺杆菌(Helicobacter pylori,H.pylori)感染特点,为该地区儿童H.pylori感染的预防、诊断和治疗提供帮助。方法对2016年6月至2021年6月青岛地区因“反复腹痛、恶心、呕吐、便血”等症状就诊于青岛大学附属医院的490例患儿进行胃镜检查,根据组织病理结果和¹³C呼气试验检测评估患儿H.pylori感染情况,并根据收集的临床资料进行统计学分析。结果 490例患儿H.pylori总感染率为21.8%。其中男性患儿的感染率为28.1%,女性患儿的感染率为12.6%,差异有统计学意义(P<0.05)。不同年龄段H.pylori感染率比较,差异无统计学意义(P>0.05),但对7~14岁年龄段患儿进行分析发现,该年龄段患儿H.pylori感染率随年龄增加呈上升趋势。父母受教育程度高的患儿H.pylori感染率低于父母受教育程度低的患儿,差异有统计学意义(P<0.05)。对107例H.pylori感染患儿胃黏膜组织进行病理分析,107例患儿中炎症程度轻度4例(3.7%),中度98例(91.6%),重度5例(4.7%),炎症活动度轻度50例(46.7%),中度54例(50.5%),重度3例(2.8%)。结论青岛地区儿童H.pylori感染率较高,且7~14岁年龄段患儿H.pylori感染率随年龄增加呈上升趋势。青岛地区儿童H.pylori感染与性别、父母受教育程度有关。H.pylori感染阳性患儿胃黏膜组织病理提示,炎症程度中度患儿较多,炎症活动度以轻度及中度为主。

关键词: 幽门螺杆菌, 儿童, 青岛地区

Abstract:

Objective To understand the characteristics of Helicobacter pylori(H.pylori) infection of children in Qingdao region, and to provide aids for the prevention and treatment of H.pylori infection of children.Methods Four hundred and ninty children received gastroscopy in the Affiliated Hospital of Qingdao University for “repeated abdominal pain, nausea, vomiting, hematochezia”, and other symptoms from June 2016 to June 2021 in Qingdao region, H.pylori infections of children were examined and evaluated based on the results of histopathological and 13C breath test, and the statistical analysis was implemented according to clinical data gathered.Results The overall infection rate of 490 children with H.pylori in Qingdao region was 21.8%. The infection rate of male and female children was 28.1% and 12.6%, and the difference was statistically significant (P<0.05). None of the infection rate of H.pylori differed significantly in different age groups (P>0.05), while the analysis on children aged 7~14 years old showed that the infection rate of H.pylori increased with the age. The H.pylori infection rate of children with highly educated parents was lower than that of children with low educated parents, and with statistically significant difference (P<0.05); the pathological examination of gastric mucosa in 107 children with H.pylori infection showed that there were 4 cases (3.7%) with mild inflammation, 98 cases (91.6%) with moderate inflammation and 5 cases (4.7%) with severe inflammation for inflammation degree as well as 50 mild cases (46.7%), 54 moderate cases (50.5%) and 3 severe cases (2.8%) for inflammatory activity among 107 children.Conclusion The H.pylori infection rate of children in Qingdao region is high, the H.pylori infection rate increases with the age of children aged 7-14 years old. The H.pylori infection rate in children in Qingdao is correlated with gender and parents' education. Pathological examination of gastric mucosa in children infected with positive H.pylori shows that there are more children with moderate inflammation, and the inflammatory activity is mainly mild and moderate.

Key words: helicobacter pylori, children, Qingdao region

中图分类号:

R377

于敬红, 赵燕, 于淑凤, 王彩霞. 青岛地区儿童幽门螺杆菌感染调查分析[J]. 临床荟萃, 2022, 37(2): 141-144.

Yu Jinghong, Zhao Yan, Yu Shufeng, Wang Caixia. Investigation and analysis on helicobacter pylori infection of children in Qingdao region[J]. Clinical Focus, 2022, 37(2): 141-144.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2022.02.009

https://huicui.hebmu.edu.cn/CN/Y2022/V37/I2/141

图/表 5

参考文献 14

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性别	例数	H.pylori阳性[例(%)]
男	292	82(28.1)
女	198	25(12.6)
χ²值		16.510
P值		0.000

性别	例数	H.pylori阳性[例(%)]
男	292	82(28.1)
女	198	25(12.6)
χ²值		16.510
P值		0.000

年龄	例数	H.pylori阳性[例(%)]
幼儿组	7	1(14.3)
学龄前组	14	4(28.6)
小学组	377	75(19.9)
初中组	92	27(32.6)
χ²值		4.481
P值		0.079

年龄	例数	H.pylori阳性[例(%)]
幼儿组	7	1(14.3)
学龄前组	14	4(28.6)
小学组	377	75(19.9)
初中组	92	27(32.6)
χ²值		4.481
P值		0.079

受教育程度	例数	H.pylori阳性[例(%)]
普通教育	146	41(28.1)
高等教育	227	39(17.2)
χ²值		6.270
P值		0.009