SLP-2在胃癌中的表达及临床意义的Meta分析

doi:10.3969/j.issn.1004-583X.2022.04.002

摘要/Abstract

摘要：

目的系统评价SLP-2在胃癌中的表达及其与临床病理参数的相关性。方法计算机检索PubMed、Cochrane Library、EMbase、CBM、CNKI、WanFang Date和VIP数据库,检索国内外关于SLP-2在胃癌中表达的病例-对照研究,检索时限为从建库至2021年11月。由2名研究者独立检索筛选文献、提取资料并评价偏倚风险,用Revman5.3软件进行meta分析。结果最终纳入8个病例-对照研究,共计1 079例患者。Meta分析结果显示:SLP-2在胃癌组织中的表达水平明显高于癌旁组织,差异有统计学意义[OR=6.20, 95%CI(4.41, 8.73), P<0.01];胃癌组织中SLP-2在不同分化程度组[OR=1.41, 95%CI(1.04, 1.93), P=0.03]、不同浸润深度组[OR=3.84, 95%CI(2.70, 5.47), P<0.01]、不同淋巴结转移组[OR=2.21, 95%CI(1.37, 3.56), P=0.001]、不同血行转移组[OR=2.05, 95%CI(1.25, 3.35), P=0.004]、不同临床分期组[OR=2.79, 95%CI(2.08, 3.74), P<0.01]中的表达水平差异均有统计学意义。结论 SLP-2在胃癌组织和癌旁组织中差异表达,在胃癌组织中的表达水平和临床病理参数相关,提示SLP-2在胃癌的发生中起作用。受到纳入文献数量与质量的限制,上述结果需要更多高质量的研究加以验证。

关键词: 胃肿瘤, stomatin样蛋白-2, Meta分析

Abstract:

Objective To evaluate the correlation of the expression and pathology parameters of SLP-2 in gastric cancer.Methods Two researchers independently collected and screened case-control studies regarding SLP-2 expression in gastric cancer in domestic and foreign databases as PubMed, Cochrane Library, EMbase, CBM, CNKI, WanFang Date and VIP databases, the construction time was until November 2021; they assessed the risk of bias for these data and used Revman5.3 software for a meta-analysis.Results Eligible 8 case-control studies were included, with a total of 1079 patients. Meta-analysis showed that the expression level of SLP-2 in gastric cancer tissues was significantly higher than that in adjacent tissues [OR=6.20,95%CI(4.41,8.73),P<0.01]. In gastric cancer tissues, the expression level of SLP-2 in groups with different degrees of differentiation [OR=1.41,95%CI(1.04,1.93),P=0.03], groups with different depth of invasion [OR=3.84,95%CI(2.70,5.47),P<0.01] and groups with different lymph node Metastasis [OR=2.21,95%CI(1.37,3.56),P=0.001], groups with different blood Metastasis [OR=2.05,95%CI(1.25,3.35),P=0.004], groups with different clinical stage [OR=2.79,95%CI(2.08,3.74),P<0.01] was found had statistical significance. Conclusion There are significant difference in SlP-2 expression between gastric cancer tissues and adjacent tissues, which is correlated with clinicopathological parameters, suggesting that SLP-2 plays a role in gastric cancer incidence. Due to the limited quantity and quality of the above literatures, the conclusions should be verified by more high-quality studies.

Key words: stomach neoplasms, stomatin-like protein-2, meta-analysis

中图分类号:

R735.2

陶嘉楠, 田王钊, 安琪, 王学红, 张盛祺, 刘吉. SLP-2在胃癌中的表达及临床意义的Meta分析[J]. 临床荟萃, 2022, 37(4): 299-304.

Tao Jianan, Tian Wangzhao, An Qi, Wang Xuehong, Zhang Shengqi, Liu Ji. Expression and clinical significance of SLP-2 in gastric cancer: A meta-analysis[J]. Clinical Focus, 2022, 37(4): 299-304.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2022.04.002

https://huicui.hebmu.edu.cn/CN/Y2022/V37/I4/299

图/表 7

参考文献 27

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纳入研究	国家及地区	例数	性别 (男/女,例)	中位年龄 (岁)	试验方法	胃癌SLP-2 阳性率(%)	癌旁SLP-2 阳性率(%)	结局指标
Li 2014^[13]	中国江苏	451	314/137	58(17-85)	IHC	69.8	-	②③④⑤⑥⑦⑧⑨
Liu 2013^[14]	中国广东	113	51/62	63(28-92)	IHC	62.8	23.3	①②③④⑤⑥⑦⑧⑨
Ma 2018^[15]	中国广东	105	70/35	-	IHC	75.2	-	②③⑤⑥⑦⑨
张剑 2013^[16]	中国河南	60	37/23	65(45-79)	IHC	68.3	25.0	①②③④⑤⑥⑦
王东建 2019^[17]	中国江苏	80	44/36	-	IHC	65.0	22.5	①②③⑥⑦
芦永福 2015^[18]	中国青海	30	-	45(34-70)	IHC	56.7	20.0	①
颜淑梅 2012^[19]	中国广东	190	130/60	58(20-82)	IHC	63.2	-	②③④⑤⑥⑦⑧⑨
饶兰 2014^[20]	中国湖北	50	32/18	-	IHC	66.0	20.0	①②③⑤⑥

纳入研究	国家及地区	例数	性别 (男/女,例)	中位年龄 (岁)	试验方法	胃癌SLP-2 阳性率(%)	癌旁SLP-2 阳性率(%)	结局指标
Li 2014^[13]	中国江苏	451	314/137	58(17-85)	IHC	69.8	-	②③④⑤⑥⑦⑧⑨
Liu 2013^[14]	中国广东	113	51/62	63(28-92)	IHC	62.8	23.3	①②③④⑤⑥⑦⑧⑨
Ma 2018^[15]	中国广东	105	70/35	-	IHC	75.2	-	②③⑤⑥⑦⑨
张剑 2013^[16]	中国河南	60	37/23	65(45-79)	IHC	68.3	25.0	①②③④⑤⑥⑦
王东建 2019^[17]	中国江苏	80	44/36	-	IHC	65.0	22.5	①②③⑥⑦
芦永福 2015^[18]	中国青海	30	-	45(34-70)	IHC	56.7	20.0	①
颜淑梅 2012^[19]	中国广东	190	130/60	58(20-82)	IHC	63.2	-	②③④⑤⑥⑦⑧⑨
饶兰 2014^[20]	中国湖北	50	32/18	-	IHC	66.0	20.0	①②③⑤⑥

纳入研究	①	②	③	④	⑤	⑥	⑦	⑧	NOS评分(分)
Li 2014^[13]	1	1	1	1	2	1	1	1	9
Liu 2013^[14]	1	1	1	0	1	1	1	1	7
Ma 2018^[15]	1	1	1	1	1	1	1	1	8
张剑 2013^[16]	1	1	1	1	2	1	1	1	9
王东建 2019^[17]	1	1	1	1	1	1	1	1	8
芦永福 2015^[18]	1	1	1	1	1	1	1	1	8
颜淑梅 2012^[19]	1	1	1	0	2	1	1	1	8
饶兰 2014^[20]	1	1	1	1	2	1	1	1	9

纳入研究	①	②	③	④	⑤	⑥	⑦	⑧	NOS评分(分)
Li 2014^[13]	1	1	1	1	2	1	1	1	9
Liu 2013^[14]	1	1	1	0	1	1	1	1	7
Ma 2018^[15]	1	1	1	1	1	1	1	1	8
张剑 2013^[16]	1	1	1	1	2	1	1	1	9
王东建 2019^[17]	1	1	1	1	1	1	1	1	8
芦永福 2015^[18]	1	1	1	1	1	1	1	1	8
颜淑梅 2012^[19]	1	1	1	0	2	1	1	1	8
饶兰 2014^[20]	1	1	1	1	2	1	1	1	9