临床荟萃 ›› 2022, Vol. 37 ›› Issue (6): 551-555.doi: 10.3969/j.issn.1004-583X.2022.06.014
收稿日期:
2022-04-13
出版日期:
2022-06-20
发布日期:
2022-08-05
通讯作者:
杨晓红
E-mail:13933058601@163.com
Received:
2022-04-13
Online:
2022-06-20
Published:
2022-08-05
摘要:
心血管疾病是世界范围内危害人类生命和健康的第一杀手,其发病机制多与炎症反应相关。单核细胞/高密度脂蛋白胆固醇的比值(monocyte to high-density lipoprotein cholesterol ratio,MHR)是一种潜在的反映炎症状态的生物标志物,整合了机体炎症状态及抗炎能力,其被证实与多种心血管疾病相关。本文就MHR在冠状动脉疾病、高血压、心房颤动、心力衰竭、代谢综合征、急性主动脉夹层等多种心血管疾病中的研究进展进行综述,旨在为心血管疾病的危险分层及预后提供依据。
中图分类号:
张怡, 崔晓冉, 杨晓红. 单核细胞/高密度脂蛋白胆固醇比值在心血管疾病中研究进展[J]. 临床荟萃, 2022, 37(6): 551-555.
[1] |
Han J, Chen D, Liu D, et al. Modafinil attenuates inflammation via inhibiting Akt/NF-κB pathway in apoE-deficient mouse model of atherosclerosis[J]. Inflammopharmacology, 2018, 26(2):385-393.
doi: 10.1007/s10787-017-0387-3 URL |
[2] |
Wolf D, Ley K. Immunity and inflammation in atherosclerosis[J]. Circ Res, 2019, 124(2):315-327.
doi: 10.1161/CIRCRESAHA.118.313591 URL |
[3] | Li JY, Yao RQ, Liu SQ, et al. Efficiency of Monocyte/high-density lipoprotein cholesterol ratio combined with neutrophil/lymphocyte ratio in predicting 28-day mortality in patients with sepsis[J]. Front Med (Lausanne), 2021, 8:741015. |
[4] |
Khosravi M, Poursaleh A, Ghasempour G, et al. The effects of oxidative stress on the development of atherosclerosis[J]. Biol Chem, 2019, 400(6): 711-732.
doi: 10.1515/hsz-2018-0397 pmid: 30864421 |
[5] |
Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease[J]. Int Urol Nephrol, 2014, 46(8):1619-1625.
doi: 10.1007/s11255-014-0730-1 URL |
[6] |
Hatamnejad MR, Heydari AA, Salimi M, et al. The utility of SYNTAX score predictability by electrocardiogram parameters in patients with unstable angina[J]. BMC Cardiovasc Disord, 2022, 22(1):8.
doi: 10.1186/s12872-022-02455-6 URL |
[7] |
Akboga MK, Balci KG, Maden O, et al. Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease[J]. Biomark Med, 2016, 10(4):375-383.
doi: 10.2217/bmm-2015-0050 URL |
[8] | Çaˇgdaᶊ M, Karakoyun S, Yesin M, et al. The Association between Monocyte HDL-C Ratio and SYNTAX Score and SYNTAX Score II in STEMI patients treated with primary PCI[J]. Acta Cardiol Sin, 2018, 34(1):23-30. |
[9] |
Cetin MS, Ozcan Cetin EH, Kalender E, et al. Monocyte to HDL cholesterol ratio predicts coronary artery disease severity and future major cardiovascular adverse events in acute coronary syndrome[J]. Heart Lung Circ, 2016, 25(11):1077-1086.
doi: 10.1016/j.hlc.2016.02.023 URL |
[10] |
Her AY, Shin ES. Current management of in-stent restenosis[J]. Korean Circ J, 2018, 48(5):337-349.
doi: 10.4070/kcj.2018.0103 URL |
[11] |
Zheng X, Xu K, Yang X, et al. Association between coronary artery calcium score and in-stent restenosis after drug-eluting stent implantation[J]. Coron Artery Dis, 2022, 33(4):284-294.
doi: 10.1097/MCA.0000000000001124 URL |
[12] | Avci II, Sahin I, Gungor B, et al. Association of monocyte to high-density lipoprotein ratio with bare-metal stent restenosis in STEMI patients treated with primary PCI[J]. North Clin Istanb, 2019, 6(4):393-400. |
[13] |
Nan J, Meng S, Hu H, et al. The predictive value of monocyte count to high-density lipoprotein cholesterol ratio in restenosis after drug-eluting stent implantation[J]. Int J Gen Med, 2020, 13:1255-1263.
doi: 10.2147/IJGM.S275202 URL |
[14] |
Huang Q, Zhang F, Chen S, et al. Clinical characteristics in patients with coronary slow flow phenomenon: A retrospective study[J]. Medicine (Baltimore), 2021, 100(6): e24643.
doi: 10.1097/MD.0000000000024643 URL |
[15] |
Canpolat U, Çetin EH, Cetin S, et al. Association of monocyte-to-HDL cholesterol ratio with slow coronary flow is linked to systemic inflammation[J]. Clin Appl Thromb Hemost, 2016, 22(5):476-482.
doi: 10.1177/1076029615594002 URL |
[16] |
Annibali G, Scrocca I, Aranzulla TC, et al. “No-reflow” phenomenon: A contemporary review[J]. J Clin Med, 2022, 11(8):2233.
doi: 10.3390/jcm11082233 URL |
[17] |
Celik T, Balta S, Mikhailidis DP, et al. The relation between no-reflow phenomenon and complete blood count parameters[J]. Angiology, 2017, 68(5):381-388.
doi: 10.1177/0003319716659193 URL |
[18] |
Celik T, Balta S, Demır M, et al. Predictive value of admission red cell distribution width-platelet ratio for no-reflow phenomenon in acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention[J]. Cardiol J, 2016, 23(1):84-92.
doi: 10.5603/CJ.a2015.0070 URL |
[19] |
Balta S, Celik T, Ozturk C, et al. The relation between monocyte to HDL ratio and no-reflow phenomenon in the patients with acute ST-segment elevation myocardial infarction[J]. Am J Emerg Med, 2016, 34(8):1542-1547.
doi: 10.1016/j.ajem.2016.05.031 URL |
[20] | Kalyoncuoglu M, Biter Hİ, Ozturk S, et al. Predictive accuracy of lymphocyte-to-monocyte ratio and monocyte to high-density lipoprotein cholesterol ratio in determining the slow flow/no-reflow phenomenon in patients with non-ST-elevated myocardial infarction[J]. Coron Artery Dis, 2020, 31(6):518-526 |
[21] |
Aydin E, Ates I, Fettah Arikan M, et al. The ratio of monocyte frequency to HDL cholesterol level as a predictor of asymptomatic organ damage in patients with primary hypertension[J]. Hypertens Res, 2017, 40(8):758-764.
doi: 10.1038/hr.2017.36 pmid: 28275231 |
[22] | Kaplan IG, Kaplan M, Abacioglu OO, et al. Monocyte/HDL ratio predicts hypertensive complications[J]. Bratisl Lek Listy, 2020, 121(2):133-136. |
[23] | 中华医学会心血管病学分会. 中国高血压防治指南2018年修订版[J]. 中国心血管杂志, 2019, 24(1):1-44. |
[24] |
Gembillo G, Siligato R, Cernaro V, et al. Monocyte to HDL ratio: A novel marker of resistant hypertension in CKD patients[J]. Int Urol Nephrol, 2022, 54(2):395-403.
doi: 10.1007/s11255-021-02904-9 URL |
[25] |
Ran H, Schneider M, Wan LL, et al. Four-dimensional volume-strain expression in asymptomatic primary hypertension patients presenting with subclinical left atrium-ventricle dysfunction[J]. Cardiology, 2020, 145(9):578-588.
doi: 10.1159/000508887 URL |
[26] |
Celik AI, Karaaslan MB. Role of monocyte to high-density lipoprotein cholesterol ratio in predicting left atrial enlargement in hypertensive patients[J]. Rev Assoc Med Bras (1992), 2021, 67(5):702-707.
doi: 10.1590/1806-9282.20201127 URL |
[27] | Staerk L, Wang B, Preis SR, et al. Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: Cohort study based on longitudinal data from the Framingham Heart Study[J]. BMJ, 2018, 361:k1453. |
[28] |
Scott L Jr, Li N, Dobrev D. Role of inflammatory signaling in atrial fibrillation[J]. Int J Cardiol, 2019, 287:195-200.
doi: 10.1016/j.ijcard.2018.10.020 URL |
[29] | El-Shetry M, Mahfouz R, Frere AF, et al. The interplay between atrial fibrillation and acute myocardial infarction[J]. Br J Hosp Med (Lond), 2021, 82(2): 1-9. |
[30] | 李虹敏, 张跃, 袁梦, 等. 单核细胞与高密度脂蛋白胆固醇比值对老年急性心肌梗死患者新发心房颤动的预测价值[J]. 中华老年心脑血管病杂志, 2021, 23(3):229-232. |
[31] |
Ulus T, Isgandarov K, Yilmaz AS, et al. Predictors of new-onset atrial fibrillation in elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention[J]. Aging Clin Exp Res, 2018, 30(12): 1475-1482.
doi: 10.1007/s40520-018-0926-9 URL |
[32] |
Calkins H, Hindricks G, Cappato R, et al. 2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation:Executive summary[J]. Europace, 2018, 20(1):157-208.
doi: 10.1093/europace/eux275 URL |
[33] |
Chen SA, Zhang MM, Zheng M, et al. The preablation monocyte/ high density lipoprotein ratio predicts the late recurrence of paroxysmal atrial fibrillation after radiofrequency ablation[J]. BMC Cardiovasc Disord, 2020, 20(1):401.
doi: 10.1186/s12872-020-01670-3 URL |
[34] |
Canpolat U, Aytemir K, Yorgun H, et al. The role of preprocedural monocyte-to-high-density lipoprotein ratio in prediction of atrial fibrillation recurrence after cryoballoon-based catheter ablation[J]. Europace, 2015, 17(12):1807-1815.
doi: 10.1093/europace/euu291 pmid: 25995388 |
[35] |
Yamanaka K, Nishina T, Iwakura A, et al. Long-term results of the maze procedure with GP ablation for permanent atrial fibrillation[J]. Gen Thorac Cardiovasc Surg, 2021, 69(2):230-237.
doi: 10.1007/s11748-020-01438-8 URL |
[36] | Adili A, Wang Y, Zhu X, et al. Preoperative monocyte-to-HDL-cholesterol ratio predicts early recurrence after radiofrequency maze procedure of valvular atrial fibrillation[J]. J Clin Lab Anal, 2021, 35(2):e23595. |
[37] |
Tekkesin AI, Hayiroglu MI, Zehir R, et al. The use of monocyte to HDL ratio to predict postoperative atrial fibrillation after aortocoronary bypass graft surgery[J]. North Clin Istanb, 2017, 4(2):145-150.
doi: 10.14744/nci.2017.53315 pmid: 28971172 |
[38] | Thrane PG, Kristensen SD, Olesen K, et al. 16-year follow-up of the Danish Acute Myocardial Infarction 2 (DANAMI-2) trial: primary percutaneous coronary intervention vs. fibrinolysis in ST-segment elevation myocardial infarction[J]. Eur Heart J, 2020, 41(7):847-854. |
[39] |
Chen Q, Yin Q, Song J, et al. Identification of monocyte-associated genes as predictive biomarkers of heart failure after acute myocardial infarction[[J]. BMC Med Genomics, 2021, 14(1):44.
doi: 10.1186/s12920-021-00890-6 URL |
[40] |
Hunter WG, McGarrah RW 3rd, Kelly JP, et al. High-density lipoprotein particle subfractions in heart failure with preserved or reduced ejection fraction[J]. J Am Coll Cardiol, 2019, 73(2):177-186.
doi: S0735-1097(18)39181-2 pmid: 30654890 |
[41] | 周琼, 张洁钰, 张菲斐. 糖尿病合并射血分数保留心力衰竭患者单核细胞/高密度脂蛋白胆固醇比率与N末端B型利钠肽原水平相关性[J]. 中国医药导报, 2017, 14(5):55-58. |
[42] |
Rochlani Y, Pothineni NV, Kovelamudi S, et al. Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds[J]. Ther Adv Cardiovasc Dis, 2017, 11(8):215-225.
doi: 10.1177/1753944717711379 pmid: 28639538 |
[43] |
Reddy P, Lent-Schochet D, Ramakrishnan N, et al. Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes[J]. Clin Chim Acta, 2019, 496:35-44.
doi: 10.1016/j.cca.2019.06.019 URL |
[44] |
Uslu AU, Sekin Y, Tarhan G, et al. Evaluation of monocyte to high- density lipoprotein cholesterol ratio in the presence and severity of metabolic syndrome[J]. Clin Appl Thromb Hemost, 2018, 24(5):828-833.
doi: 10.1177/1076029617741362 URL |
[45] |
Du X, Zhang S, Xu J, et al. Diagnostic value of monocyte to high-density lipoprotein ratio in acute aortic dissection in a Chinese han population[J]. Expert Rev Mol Diagn, 2020, 20(12):1243-1252.
doi: 10.1080/14737159.2020.1847647 URL |
[46] |
Evangelista A, Isselbacher EM, Bossone E, et al. Insights from the international registry of acute aortic dissection:a 20-year experience of collaborative clinical research[J]. Circulation, 2018, 137(17): 1846-1860.
doi: 10.1161/CIRCULATIONAHA.117.031264 pmid: 29685932 |
[47] |
Xie E, Yang F, Luo S, et al. Association between preoperative monocyte to high-density lipoprotein ratio on in-hospital and long-term mortality in patients undergoing endovascular repair for acute type b aortic dissection[J]. Front Cardiovasc Med, 2021, 8:775471.
doi: 10.3389/fcvm.2021.775471 URL |
[48] |
Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: Implications for cardiac and vascular disease[J]. JAMA, 2003, 290(14): 1906-1914.
pmid: 14532320 |
[49] |
Iannella G, Magliulo G, Greco A, et al. Obstructive sleep apnea syndrome: From symptoms to treatment[J]. Int J Environ Res Public Health, 2022, 19(4) :2459.
doi: 10.3390/ijerph19042459 URL |
[50] |
Wang F, Zhang LY, Zhang P, et al. Effect of physical activity on hospital service use and expenditures of patients with coronary heart disease: Results from Dongfeng-Tongji Cohort Study in China[J]. Curr Med Sci, 2019, 39(3):483-492.
doi: 10.1007/s11596-019-2063-x URL |
[51] |
Wang HY, Shi WR, Yi X, et al. Assessing the performance of monocyte to high-density lipoprotein ratio for predicting ischemic stroke: Insights from a population-based Chinese cohort[J]. Lipids Health Dis, 2019, 18(1):127.
doi: 10.1186/s12944-019-1076-6 URL |
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