线粒体转录因子A介导的线粒体功能障碍在糖尿病心肌病中的作用

doi:10.3969/j.issn.1004-583X.2023.05.015

摘要/Abstract

摘要：

目前糖尿病心血管并发症的发病率和病死率不断提高,其中糖尿病心肌病这一独立于冠状动脉疾病、高血压心脏病和心脏瓣膜病以外的以代谢障碍和心功能障碍为特征的心血管并发症的发生与线粒体功能障碍有关。研究表明,线粒体转录因子A(mitochondrial transcription factor A,TFAM)的表达异常可使线粒体功能障碍,而高糖环境可使TFAM表达降低。本文就线粒体功能紊乱致糖尿病心肌病的发生机制、TFAM对心肌细胞线粒体功能的影响、TFAM介导的线粒体功能障碍在糖尿病心肌病发生发展中的作用进行综述,以期为临床糖尿病心肌病的诊治提供理论依据。

关键词: 糖尿病心肌病, 线粒体转录因子A, 线粒体功能, 氧化应激, DNA, 线粒体, 细胞凋亡

中图分类号:

R542.2

吕丽丽, 翟满满, 丁小艳, 陈永清. 线粒体转录因子A介导的线粒体功能障碍在糖尿病心肌病中的作用[J]. 临床荟萃, 2023, 38(5): 465-468.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2023.05.015

https://huicui.hebmu.edu.cn/CN/Y2023/V38/I5/465

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