临床荟萃 ›› 2024, Vol. 39 ›› Issue (5): 389-395.doi: 10.3969/j.issn.1004-583X.2024.05.001

• 循证研究 •    下一篇

超声造影对局灶性睾丸病变诊断价值的meta分析

高铭, 刘昊, 于航, 林霖, 张紫杰, 熊颖()   

  1. 民航总医院 超声医学科,北京 100123
  • 收稿日期:2023-11-20 出版日期:2024-05-20 发布日期:2024-07-05
  • 通讯作者: 熊颖,Email: 1830616807@qq.com

Diagnostic value of contrast-enhanced ultrasound in differentiating focal testicular lesions: A meta-analysis

Gao Ming, Liu Hao, Yu Hang, Lin Lin, Zhang Zijie, Xiong Ying()   

  1. Department of Ultrasound, Civil Aviation General Hospital, Beijing 100123, China
  • Received:2023-11-20 Online:2024-05-20 Published:2024-07-05
  • Contact: Xiong Ying, Email: 1830616807@qq.com

摘要:

目的 系统评价超声造影(contrast-enhanced ultrasound, CEUS)对局灶性睾丸病变的诊断价值。方法 检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方、维普(VIP)数据库,收集从建库至2023年8月10日发表的关于CEUS诊断局灶性睾丸病变的相关文献,根据纳入和排除标准筛选文献、提取数据,并行文献质量评价,采用RevMan5.4、Meta disc1.4及Stata15.0软件分析CEUS在睾丸肿瘤与肿瘤样病变、肿瘤良恶性两个方面的诊断效能。结果 最终纳入13篇文献共712个病灶。Meta分析结果显示,CEUS诊断睾丸肿瘤与肿瘤样病变的合并敏感度、特异度、阳性似然比、阴性似然比分别为0.95(95%CI:0.87~0.98)、0.84(95%CI:0.73~0.91)、5.8(95%CI:3.3~10.2)、0.06(95%CI:0.02~0.17),合并受试者工作特征曲线下面积为0.94(95%CI:0.92~0.96);CEUS诊断睾丸良恶性病变的合并敏感度、特异度、阳性似然比、阴性似然比分别为0.95(95%CI:0.85~0.99)、0.81(95%CI:0.65~0.90)、4.9(95%CI:2.5~9.6)、0.06(95%CI:0.02~0.20),合并受试者工作特征曲线下面积为0.96(95%CI:0.94~0.97)。结论 CEUS对局灶性睾丸病变具有较高的诊断价值,能为临床诊疗提供参考。

关键词: 超声造影, 局灶性睾丸病变, 睾丸肿瘤与肿瘤样病变, 肿瘤良恶性病变, Meta分析

Abstract:

Objective To evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in focal testicular lesions. Methods Relevant studies regarding CEUS in differentiating focal testicular lesions which reported from the establishment of the databases to August 10, 2023 were retrieved from databases including PubMed, EMBASE, Cochrane Library, Web of Science, China BioMedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP Data. Eligible documents were conducted for data extraction, quality evaluation. RevMan 5.4, Meta disc1.4 and Stata15.0 were employed to analyze the diagnostic performance of CEUS for differentiating testicular lesions in tumor-like lesions and differentiation of benign and malignant. Results Thirteen original studies representing 712 lesions were included. Meta analysis showed that the pooled sensitivity, specificity, positive likelihood radio and negative likelihood ratio of CEUS for differentiating testicular neoplastic tumors in tumor-like lesions were 0.95(95%CI: 0.87-0.98), 0.84(95%CI: 0.73-0.91), 5.8(95%CI: 3.3-10.2), 0.06(95%CI: 0.02-0.17), respectively, and the area under the curve (AUC) for the summary receiver operating characteristic (SROC) was 0.94 (95%CI: 0.92-0.96). The pooled sensitivity, specificity, positive likelihood radio and negative likelihood ratio of CEUS for differentiating testicular lesions in differentiation of benign and malignant were 0.95(95%CI: 0.85-0.99), 0.81(95%CI: 0.65-0.90), 4.9 (95%CI: 2.5-9.6), 0.06(95%CI: 0.02-0.20), respectively, and the AUC for SROC was 0.96(95%CI: 0.94-0.97). Conclusion CEUS has a high diagnostic value for focal testicular lesions and can provide a reference for clinical diagnosis and treatment.

Key words: contrast-enhanced ultrasound, focal testicular lesions, neoplastic tumors and tumor-like lesions, benign and malignant neoplasms, Meta analysis

中图分类号: