Influence of pregnancy hyperthyroidism on offspring brain development

doi:10.3969/j.issn.1004-583X.2016.03.007

Abstract

Abstract: Thyroid hormone (TH) is the key to brain development. Thyroid dysfunction during pregnancy can lead to the change of brain tissue and the cell structure. This review illustrates the adverse effect of thyroid hormone on fetal brain development from hyperthyroidism and mechanism of pregnant physiology and thyroid hormone. The conclusion was that hyperthyroidism during pregnancy may affect fetal brain development and needs active treatment.

Key words: atrialfibrillation, anticoagulanttherapy, warfarin, percutaneousleftatrialappendageocclusion, hyperthyroidism, thyroid hormones, cerebrum, pregnancy

CLC Number:

R581.1

Liu Zhihong,Wang Ruiying. Influence of pregnancy hyperthyroidism on offspring brain development[J]. Clinical Focus, 2016, 31(3): 258-261.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.03.007

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I3/258

References

[1] 单忠艳.妊娠合并甲状腺功能减退症的进展和争论[J].内科理论与实践,2010,5 (2):125-129.
[2] Chan GW, Mandel SJ. Therapy insight: management of Graves’ disease during pregnancy[J]. Nat Clin Pract Endocrinol Metab,2007, 3(6): 470-478.
[3] Haddow JE, McClain MR, Lambert-Messerlian G,et al. Variability in thyroid-stimulating hormone suppression by human chorionic [corrected]gonadotropin during early pregnancy[J]. J Clin Endocrinol Metab, 2008, 93(9): 3341-3347.
[4] Gaberˇcek S, Zaletel K, et al.Thyroid physiology and autoimmunity in pregnancy and after delivery[J]. Clin Immunol, 2011, 7(5): 697-706.
[5] Fister P, Gaberscek S, Zaletel K, et al. Thyroid volume changes during pregnancy and after delivery in an iodine-sufficient Republic of Slovenia[J]. Eur J Obstet Gynecol Reprod Biol,2009, 145(1): 45-48.
[6] Chan SY, Vasilopoulou E, Kilby MD. The role of the placenta in thyroid hormone delivery to the fetus[J].Nat Clin Pract Endocrinol Metab,2009,5(1):45-54.
[7] Wallis K,Dudazy S,Van Hogerlinden M,et al. The thyroid hormone receptor alphal protein is expressed in embryonic postmitotic neurons and persists in most adult neurons[J].Mol Endocrinol,2010,24(10):1904-1916.
[8] Calzà L,Fernández M,Giardino L. Role of the thyroid system in myelination and neural connectivity[J].Compr Physiol,2015, 5(3):1405-1421.
[9] Bhumika S, Darras VM. Role of thyroid hormones in different aspects of nervous system regeneration in vertebrates[J]. Gen Comp Endocrinol, 2014,203:86-94.
[10] Gong J, Liu W, Dong J,et al. Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180[J].BMC Neurosci,2010,11:50.
[11] 叶启宝, 朱德发, 贾雪梅,等. 成年期甲减大鼠海马Muncl8表达及甲状腺素的治疗效应[J]. 安徽医科大学学报, 2009,44(4): 423-426.
[12] Wang F,Zeng X, Zhu Y,et al. Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats[J]. Mol Med Rep,2015,11(2): 775-782.
[13] Zhang HM, Su Q, Luo M. Thyroid hormone regulates the expression of SNAP-25 during rat brain development[J]. Mol Cell Biochem, 2008, 307(1/2): 169-175.
[14] Erdamar H, Demirci H, Yaman H, et al. The effect of hypothyroidism,hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status[J].Clin Chem Lab Med, 2008,46(7):1004-1010.
[15] 王建月, 王茜, 孙春萍,等. 甲状腺激素对成年大鼠额叶内 synaptotagmin 1 表达的影响[J]. 安徽医科大学学报, 2010, 45(6): 752-755.
[16] Giordano T, Pan JB, Casuto D, et al. Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain[J]. Brain Res Mol Brain Res, 1992,16(3-4): 239-245.
[17] Roberts CG, Ladenson PW. Hypothyroidism[J]. Lancet, 2004, 363(9411): 793- 803.
[18] Vogel A,Elberling TV,Hrding M,et al.Affective symptoms and cognitive functions in the acute phase of Graves'thyrotoxicosis[J].Psychoneuroendocrinology,2007,32(1):36-43.
[19] Ceresini G, Lauretani F, Maqqio M, et al. Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study[J]. J Am Geriatr Soc, 2009, 57(1): 89-93.
[20] Mnnist T, Mendola P, Grewal J,et al.Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort[J]. J Clin Endcrinol Metab, 2013, 98(7):2725-2733.
[21] Andersen SL, Olsen J, Wu CS,et al. Spontaneous abortion, stillbirth and hyperthyroidism: a danish population-based study[J]. Eur Thyroid J,2014, 3(3): 164-172.
[22] Millar LK,Wing DA,Leung AS,et al,Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism[J].Obstet Gynecol,1994,84(6):946-949.
[23] Momotani N,Noh JY,Ishikawa N,et al.Effects of propylthiouracil and methimazole on fetal thyroid status in mothers with Graves' hyperthyroidism[J].J Clin Endocrinol Metab,1997,82:3633-3636.
[24] Péter F, Muzsnai A. Congenital disorders of the thyroid: hypo/hyper[J]. Pediatr Clin North Am,2011,58(5): 1099-1115.
[25] Ahmed OM, Abd El-Tawab SM, Ahmed RG. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones neurotrans- mitters and adenosinergic system interactions[J].Int Dev Neurosci,2010,28(6): 437-454.