Functional cure of chronic hepatitis B: current status and perspectives

doi:10.3969/j.issn.1004-583X.2016.07.001

Abstract

Abstract: Treatment of chronic hepatitis B (CHB) with nucleos(t)ide analogs (NA) and interferonα (IFNα) can lead to a significant suppression of viral replication， as well as reduced risk of disease progression and hepatocellular carcinoma. However， challenge remains regarding curing CHB because hepatic covalently closed circular DNA can not be completely eradicated. Discovering new drugs targeted hepatitis B virus may enable the possibility of functional curing CHB in future. Among available therapeutic strategies， switching to or sequential combination with IFNα in patients with longterm NA treatment can induce increased percentages of responses， even make the likelihood of functional cure in a proportion of patients.

Key words: hepatitis B, chronic, antiviral agents, therapeutics, hepatitis B surface antigens

Shen Chuan1， Wang Jing2， Zhao Caiyan1， Zhang Wenhong2. Functional cure of chronic hepatitis B: current status and perspectives[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2016.07.001.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2016.07.001

https://huicui.hebmu.edu.cn/EN/Y2016/V31/I7/697

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Functional cure of chronic hepatitis B: current status and perspectives

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