Abstract: ObjectiveTo analyze the incidence and risk factors of  type 1  cardiorenal  syndrome (CRS) in patients with acute coronary syndrome (ACS).MethodsConsecutive patients with ACS who were admitted to our department were enrolled in this study from January 2015 to April 2015. All the eligible cases were divided to CRS group and control group according to the incidence of type 1 CRS. The baseline clinical characteristics and the procedure of coronary interventions were recorded and compared. The incidence of major adverse events (MACE) were followed up. Logistic regression analysis was used for the predictor of type 1 CRS in ACS patients.ResultsA total of 109 patients with ACS were enrolled，the average age was 59.3±9.0 years old， and 84 cases were male. The incidence of type 1 CRS was 10.1%. STEMI patients were more common (72.7% vs 23.5%，P=0.002)， GRACE and CRUSADE scores were higher in  CRS group compared with those of control group (both P<0.01). The incidence of sudden death before admission was higher (36.4% vs 2.0%，P<0.01)  and HCT was lower (P=0.049)  in CRS group compared to the control group. The peak levels of CK and cTnI were higher in CRS group than those in the control group， while LVEF and E/e’ were lower. No significance of interventional characteristics were found except ratio of multivessel diseases. During the hospitalization， the incidences of MACE (45.5% vs 16.3%，P=0.020) and heart failure were higher in CRS group than those in the control group (18.2% vs 0%，P=0.009). Logistic regression analysis showed that the baseline level of serum creatinin(SCr) and peak value of cTnI were independent risks of type 1 CRS in patients with ACS during the hospitalization (both P<0.05).ConclusionACS combined with type 1 CRS patients in poor prognosis， high cTnI peak and increased SCr level at admission were risks for type 1 ACS in patients with CRS.

Key words: acute coronary syndrome, cardiorenal syndrome, major adverse cardiac events