Clinical efficacy of lidocaine combined with rosuvastatin in treating acute coronary syndrome concurrent with acute arrhythmia among patients intolerant of amiodarone

doi:10.3969/j.issn.1004-583X.2021.04.003

Abstract

Abstract:

Objective To investigate the effects of lidocaine combined with rosuvastatin in treating acute coronary syndrome(ACS) concurrent with acute arrhythmia among patients intolerant of amiodarone. Methods A total of 110 patients with ACS who were intolerant of amiodarone were recruited from our hospital, and they were divided into two groups, the control group (n=55) were given thrombolytic therapy, the observation group (n=55) were given idocaine combined with rosuvastatin. The both groups were treated with thrombolysis and low molecular weight heparin, and the changes in clinical efficacy, cardiac function, inflammatory factors and oxidative stress indicators were compared between two groups. Results The total response rate in the observation group was significantly higher than that in the control group (96.36% vs 85.45%,P<0.05). After treatment, the indexes of heart rate variability (HRV) in the observation group were higher than those in control group (P<0.05); HRV indexes in the observation group were higher than those in the control group (P<0.05); the serum tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein(hs-CRP) and malondialdehyde(MDA) in the observation group were lower than those in the control group, and superoxide dismutase (SOD) in the observation group was higher than that in the control group (P<0.05). Conclusion Lidocaine combined with rosuvastatin in treating ACS concurrent with acute arrhythmia among patients intolerant of amiodarone can reduce inflammatory response and oxidative stress, regulate HRV, and further improve the efficacy of antiarrhythmias.

Key words: acute coronary syndrome, amiodarone, arrhythmias, cardiac, rosuvastatin, lidocaine

CLC Number:

R542.2

Cui Guoyan, Zheng Wen, Zhang Liwei. Clinical efficacy of lidocaine combined with rosuvastatin in treating acute coronary syndrome concurrent with acute arrhythmia among patients intolerant of amiodarone[J]. Clinical Focus, 2021, 36(4): 311-314.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.04.003

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I4/311

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References 23

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组别	例数	显效	有效	无效	总有效率
对照组	55	30(54.55)	17(30.91)	8(14.55)	47(85.45)
观察组	55	34(61.82)	19(34.55)	2(3.64)	53(96.36)
χ²值		0.598	0.165	3.960	3.960
P值		0.439	0.684	0.047	0.047

组别	例数	显效	有效	无效	总有效率
对照组	55	30(54.55)	17(30.91)	8(14.55)	47(85.45)
观察组	55	34(61.82)	19(34.55)	2(3.64)	53(96.36)
χ²值		0.598	0.165	3.960	3.960
P值		0.439	0.684	0.047	0.047

组别	例数	SDNN(ms)		SDANN(ms)		RMSSD(ms)		pNN50(%)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	55	83.29±13.49	105.28±9.81^*	84.82±12.89	104.95±9.59^*	20.24±6.89	27.53±6.93^*	5.82±1.24	8.12±2.59^*
对照组	55	82.75±12.64	94.82±8.95^*	84.53±13.32	93.94±9.07^*	21.23±7.04	24.13±5.42^*	5.62±1.36	6.95±2.14^*
t值		0.217	5.842	0.116	6.186	0.745	2.866	0.806	2.583
P值		0.829	<0.01	0.907	<0.01	0.458	0.005	0.422	0.011

组别	例数	SDNN(ms)		SDANN(ms)		RMSSD(ms)		pNN50(%)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
观察组	55	83.29±13.49	105.28±9.81^*	84.82±12.89	104.95±9.59^*	20.24±6.89	27.53±6.93^*	5.82±1.24	8.12±2.59^*
对照组	55	82.75±12.64	94.82±8.95^*	84.53±13.32	93.94±9.07^*	21.23±7.04	24.13±5.42^*	5.62±1.36	6.95±2.14^*
t值		0.217	5.842	0.116	6.186	0.745	2.866	0.806	2.583
P值		0.829	<0.01	0.907	<0.01	0.458	0.005	0.422	0.011

组别	例数	hs-CRP(mg/L)		TNF-α(pg/ml)
组别	例数	治疗前	治疗后	治疗前	治疗后
对照组	55	16.34±2.84	11.25±2.74^*	3.04±1.53	1.95±0.52^*
观察组	55	16.42±3.01	5.71±1.38^*	3.12±1.58	1.33±0.27^*
t值		0.431	13.392	0.270	7.848
P值		0.886	0.000	0.788	0.000