Abstract: Objective  To investigate the relationship between apolipoprotein E (ApoE) gene polymorphism and shortterm prognosis in patients with acute coronary syndrome (ACS).Methods  88 patients with ACS were enrolled from October 2016 to January 2017. The patients were divided into three groups according to the polymerase chain reaction restriction fragment length polymorphism (PCRRFLP) and PCR amplification results. The baseline data， number of coronary artery vessels， GRACE score at admission， and major adverse cardiovascular events (MACE) during hospitalization and one month followup after discharge were observed and compared. Results  ①There were 25 cases of ApoE4 phenotype， 45 cases of E3 phenotype and 18 cases of E2 phenotype. ②Compared with E2 group， serum total cholesterol， low density lipoprotein cholesterol levels， coronary artery multivessels， GRACE score increased significantly in E4 group (P<0.05). ③Compared with E2 group， MACE was significantly increased in E4 group during hospitalization and at one month followup (P<0.05).Conclusion  The recent prognosis of  patients with ACS may have an important relationship with ApoE gene polymorphism. Apo E4 may play an important role in the prognosis of ACS.

Key words: acute coronary syndrome, apolipoprotein E, gene, prognosis