Abstract: Objective  To investigate the clinical efficacy of intravenous thrombolysis and endovascular therapy in Wakeup stroke (WUS) patients selected by multimode imaging. Methods  One WUS patient was treated with intravenous thrombolytic bridging arterial thrombolysis and emergency stent implantation in the 306th Hospital of PLA and followed up for 90 days. The clinical data were summarized and analyzed. Results  After intravenous thrombolysis, the symptoms were partially relieved, but aggravated again. Then thrombectomy was performed and severe middle cerebral artery stenosis was found. After thrombectomy, the blood flow could not be maintained and emergency stent implantation was given. The course of the disease was complex, however, the final outcome was good. The patient recovered with NIHSS 0 score and mRS 0 level in 90 days followup. Conclusion  For WUS patients, intravenous thrombolysis and endovascular therapy are safe and effective after multimode imaging.

Key words: brain infarction, thrombolysis, endovascular therapy