Abstract: Objective  To explore the characteristics of etiology and predisposing factors of acute ischemic stroke in Yi and Han nationalities of Liangshan Prefecture. Methods  The data of all patients who met the diagnosis of acute ischemic stroke in the department of neurology of the Second People's Hospital of Liangshan Yi Autonomous Prefecture,  from January 2017 to March 2019 were collected. The predisposing factors and TOAST classification of Yi and Han patients were analyzed. Results  Compared with Yi group, Han group had a higher proportion of hypertension,  coronary heart disease and stroke,  lower proportion of rheumatic heart disease and cigarette addiction(P＜0.05).Simultaneously,  Han group had higher levels of blood glucose,  HDLC and lower levels of LDLC,  BMI (P＜0.05). According to TOAST classification: the proportion of unexplained acute ischemic stroke in Yi group was higher than that in Han group(P＜0.05),  however,  aortic atherosclerotic stroke and arterial  lateral occlusion stroke were dominant in both groups(P＜0.05). Conclusion  The etiology and predisposing factors of acute ischemic stroke were different between Yi and Han nationalities in Liangshan Prefecture.

Key words: stroke, susceptibility factors, minority groups