Relationship between serum irisin, manganese-containing superoxide dismutase and cognitive function of patients with chronic insomnia

doi:10.3969/j.issn.1004-583X.2022.04.008

Abstract

Abstract:

Objective To detect the levels of serum irisin and manganese-containing superoxide dismutase (MnSOD) of patients with chronic insomnia, and exploring the relationship between the two and cognitive function. Methods Totally 179 patients with chronic insomnia treated in the Department of Neurology of Yellow River Central Hospital from September 2019 to December 2020 were selected, including 86 patients without cognitive impairment (group A) and 93 patients with cognitive impairment (group B). The clinical data of the two groups were retrospectively analyzed. Results Compared with group A, group B exhibited increased pittsburgh sleep quality index (PSQI) score, decreased serum irisin, MnSOD and Montreal cognitive assessment (MoCA) scores (all P<0.05). The positive correlations between serum irisin, MnSOD levels and MoCA scores in chronic insomnia patients with cognitive impairment were found (r=0.493, 0.604, all P<0.05). The decreased levels of serum iris and MnSOD were independent risk factors for cognitive impairment in patients with chronic insomnia (all P<0.05). The areas under the curve (AUC) of serum irisin and MnSOD in predicting cognitive impairment in patients with chronic insomnia were 0.805 and 0.732, respectively, with specificity of 89.5% and 58.1%, and sensitivity of 61.3% and 84.9%, respectively; the AUC, specificity and sensitivity of the combined prediction were 0.897, 95.3% and 59.1%, respectively. Conclusion Serum irisin and MnSOD levels have certain significance for cognitive impairment assessment of patients with chronic insomnia, which are closely related to cognitive function.

Key words: sleep initiation and maintenance disorders, cognition, superoxide dismutase, irisin

CLC Number:

R741

Zhai Xiayin, Lan Rui. Relationship between serum irisin, manganese-containing superoxide dismutase and cognitive function of patients with chronic insomnia[J]. Clinical Focus, 2022, 37(4): 329-333.

Add to citation manager EndNote|Ris|BibTeX

URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2022.04.008

https://huicui.hebmu.edu.cn/EN/Y2022/V37/I4/329

Figures/Tables 7

References 18

[1]	Pang R, Guo R, Wu X. et al. Altered regional homogeneity in chronic insomnia disorder with or without cognitive impairment[J]. Ajnr Am J Neuroradiol, 2018, 39(4):742-747. doi: 10.3174/ajnr.A5587 URL
[2]	夏金红, 刘万才, 蒋建萍. 温州市养老院老年人睡眠障碍的现况调查及影响因素分析[J]. 中国医师杂志, 2018, 20(3):466-468.
[3]	Siteneski A, Olescowicz G, Pazini FL. et al. Antidepressant-like and pro-neurogenic effects of physical exercise: The putative role of FNDC5/irisin pathway[J]. J Neural Transm (Vienna), 2020, 127(3):355-370.
[4]	雷雨, 刘伟, 包黎. 抑郁症患者血清鸢尾素水平与认知功能的关系[J]. 精神医学杂志, 2020, 33(4):281-283.
[5]	Kadam S, Kanitkar M, Dixit K. et al. Curcumin reverses diabetes-induced endothelial progenitor cell dysfunction by enhancing MnSOD expression and activity in vitro and in vivo[J]. J Tissue Eng Regen Med, 2018, 12(7):1594-1607. doi: 10.1002/term.2684 URL
[6]	高爱武, 杨林兴, 高淑磊, 等. 血清8-OHdG、MnSOD与高血压及阻塞性睡眠呼吸暂停低通气综合征[J]. 中国老年学杂志, 2013, 10(33):4939-4943.
[7]	中国睡眠研究会. 中国失眠症诊断和治疗指南[J]. 中华医学杂志, 2017, 97(24):1844-1856.
[8]	Chen X, Zhang R, Xiao Y. et al. Reliability and validity of the Beijing version of the montreal cognitive assessment in the evaluation of cognitive function of adult patient with OSAHS[J]. PLoS One, 2015, 10(1):e0132361. doi: 10.1371/journal.pone.0132361 URL
[9]	赵苏英. 中医护理对失眠患者的临床疗效分析[J]. 中国实用神经疾病杂志, 2017, 20(6):132-134.
[10]	Kwan Y, Baek C, Chung S. et al. Resting-state quantitative EEG characteristics of insomniac patients with depression[J]. Int J Psychophysiol, 2018, 124(1):26-32. doi: 10.1016/j.ijpsycho.2018.01.005 URL
[11]	Song GP, Yao TT, Wang D. et al. Differentiating between Alzheimer's disease, amnestic mild cognitive impairment, and normal aging via diffusion kurtosis imaging[J]. Neural Regen Res, 2019, 14(12):2141-2146. doi: 10.4103/1673-5374.262594 URL
[12]	Young MF, Valaris S, Wrann CD. A role for FNDC5/Irisin in the beneficial effects of exercise on the brain and in neurodegenerative diseases[J]. Prog Cardiovasc Dis, 2019, 62(2):172-178. doi: 10.1016/j.pcad.2019.02.007 URL
[13]	Jo D, Song J. Irisin acts via the PGC-1α and BDNF pathway to improve depression-like behavior[J]. Clin Nutr Res, 2021, 10(4):292-302. doi: 10.7762/cnr.2021.10.4.292 URL
[14]	黄腾飞, 陈莉莉. 阻塞性睡眠呼吸暂停综合征血清Irisin、SFRP5与睡眠呼吸参数和胰岛素抵抗的相关性[J]. 河北医药, 2021, 43(8):1179-1182.
[15]	秦松, 何雨峰, 况嘉铀, 等. Mn-SOD的提取及其应用研究进展[J]. 食品工业科技, 2019, 40(15):363-367.
[16]	Bulgurcuoglu KS, Iplik ES, Cakmakoglu B. et al. Relation of MPO, MnSOD, NQO1 gene variants in endometrial carcinoma in the line of PCR-RFLP methods[J]. Cell Mol Biol (Noisy-le-Grand), 2018, 64(4):78-82.
[17]	Zhang XZ, Wu BQ, Nie K. et al. Effects of acupuncture on declined cerebral blood flow, impaired mitochondrial respiratory function and oxidative stress in multi-infarct dementia rats[J]. Neurochem Int, 2014, 65(1):23-29. doi: 10.1016/j.neuint.2013.12.004 URL
[18]	Kim R, Kim HJ, Kim A. et al. Validation of the conversion between the mini-mental state examination and montreal cognitive assessment in Korean patients with Parkinson's disease[J]. J Mov Disord, 2018, 11(1):30-34.

组别	例数	年龄 (岁)	性别 (男/女)	BMI (kg/m²)	病程 (年)	受教育年限 (年)	吸烟史 [例(%)]	饮酒史 [例(%)]	PSQI评分 (分)
A组	86	68.32±7.24	38/48	21.18±2.24	6.62±2.62	11.28±2.91	29(33.7)	31(36.0)	14.98±3.36
B组	93	69.48±7.53	39/54	20.97±2.16	6.71±2.31	11.43±3.14	37(39.8)	34(36.6)	23.46±5.24
t/χ²值		1.049	0.092	0.638	0.244	0.331	0.706	0.005	12.773
P值		0.296	0.761	0.524	0.807	0.741	0.401	0.943	0.000

组别	例数	年龄 (岁)	性别 (男/女)	BMI (kg/m²)	病程 (年)	受教育年限 (年)	吸烟史 [例(%)]	饮酒史 [例(%)]	PSQI评分 (分)
A组	86	68.32±7.24	38/48	21.18±2.24	6.62±2.62	11.28±2.91	29(33.7)	31(36.0)	14.98±3.36
B组	93	69.48±7.53	39/54	20.97±2.16	6.71±2.31	11.43±3.14	37(39.8)	34(36.6)	23.46±5.24
t/χ²值		1.049	0.092	0.638	0.244	0.331	0.706	0.005	12.773
P值		0.296	0.761	0.524	0.807	0.741	0.401	0.943	0.000

组别	例数	鸢尾素 (ng/L)	MnSOD (U/ml)	MoCA评分 (分)
A组	86	3.25±0.84	10.46±3.23	27.24±1.46
B组	93	2.09±0.56	7.16±2.13	18.45±3.42
t值		10.946	8.126	22.046
P值		0.000	0.000	0.000

组别	例数	鸢尾素 (ng/L)	MnSOD (U/ml)	MoCA评分 (分)
A组	86	3.25±0.84	10.46±3.23	27.24±1.46
B组	93	2.09±0.56	7.16±2.13	18.45±3.42
t值		10.946	8.126	22.046
P值		0.000	0.000	0.000

影响因素	回归系数	标准误	Wald χ²值	P值	OR值	95%CI
影响因素	回归系数	标准误	Wald χ²值	P值	OR值	下限	上限
鸢尾素	0.772	0.297	6.764	0.009	2.165	1.210	3.875
MnSOD	0.749	0.336	4.964	0.026	2.114	1.094	4.084
PSQI评分	0.195	0.126	2.389	0.122	1.215	0.949	1.555
MoCA评分	0.124	0.114	1.183	0.277	1.132	0.905	1.415