Abstract: Objective  To evaluate the association of interferon-γ(IFN-γ)， interleukin-10(IL-10)， interleukin-17(IL-17) and helper cell T-17(Th17) cells proportion with ulcerative colitis (UC). Methods Analysis of all related literatures in PubMed (1996-2016)， CBM (1998-2016)， CNKI (1958-2016)， WanfangData (1999-2016) and VIP (19892016) was made. Randomized controlled trials involving in serum IFN-γ， IL-10， IL-17 and Th17 cells proportion in UC patients were selected. All statistical tests were performed with RevMan5.3  software. Results  A total of  20  articles and 1  151 patients were included. The results indicated that IFN-γ in UC group was significantly higher than in control group. IL-10 in UC group was significantly lower than that in control group. IL-17 in UC group was significantly higher than that in control group. Th17 cells proportion in UC group was significantly higher than that in control group.Conclusion  Existing evidences suggest that IFN-γ， IL-10， IL-17 and Th17 contribute to the pathogenesisi of UC.

Key words: colitis, ulcerative；interferongamma；interleukins