Abstract: Objective    To explore the risk factors of death with sepsis patients in EICU. Methods    Retrospectively analysis  was performed on 268 cases who admitted in EICU within more than 48 h. Epidemiological data， the worst laboratory indexes， the main intervention treatment and prognostic outcomes were recorded. The risk factors of death of septic patients in EICU were analyzed by logical regression. Results    A total of 163 cases were discharged from hospital with improved condition， 105 cases were death. The death rate was 39.2%. Multivariable logistic analysis indicated that  alanine transaminase (ALT)， aspartate transaminase (AST)， lactic acid (Lac)， shock were the independent risk factors of septic patients in EICU， urine volume (UV) and mechanical ventilation (MV) were protective factors.Conclusion    ALT， AST， Lac， shock， UV and MV are of great significance in prognosis evaluation of sepsis patients in EICU.

Key words: sepsis, intensive care unit, death, risk factors