Abstract: ObjectiveTo investigate the effect of nicorandil on the prevention of contrastinduced nephropathy(CIN).MethodsDatabases including PubMed, Cochrane Library (Issue 9,2017),VIP,WanFang Data and CNKI were electronically searched,to collect randomized controlled trials(RCTs) about nicorandil for the prevention of CIN from inception to September 2017. Two reviewers independently screened literatures,  extracted data and assessed the risk of bias of included studies. Metaanalysis was performed using  RevMan 5.3 software. ResultsA total of  5  RCTs involving 805 patients were included. The results of metaanalysis indicated that  the incidence rate of  CIN  was  significantly decreased in the nicorandil group (P=0.0002). ConclusionCurrent evidence shows that nicorandil can reduce incidence of CIN in cardiac intervention surgery patients.

Key words: nephrosis; , contrast media; , nicorandil, Metaanalysis