SARS-CoV-2 infection combined with Listeria meningitis: A case report and literature review

doi:10.3969/j.issn.1004-583X.2024.04.009

Abstract

Abstract:

Objective To improve the understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Listeria monocytogenes (LM) meningitis, thus strengthening the level of diagnosis and treatment of Listeria infections in clinicians. Methods A case of SARS-CoV-2 infection combined with LM meningitis was retrospectively analyzed, and the literatures were reviewed. Results A 77-year-old femal patient started with fever and headache, combined with SARS-CoV-2 infection, was diagnosed as LM meningitis through cerebrospinal fluid culture and blood culture. After sufficient penicillin combined with gentamicin, and meropenem subsequent for anti-infection treatment, the patient's clinical symptoms were significantly relieved, and the disease was effectively controlled. Conclusion For patients with infection of SARS-CoV-2 and immune disorders, curative care of basic diseases and improvement of immune status are the key. Once listeriosis is diagnosed, the application of sufficient and adequate treatment period of sensitive antibiotics is crucial to improve the prognosis.

Key words: meningitis, Listeria, Listeria monocytogenes, COVID-19, anti-bacterial agents

CLC Number:

Zhi Bingdi, Liu Ying, Liu Ying, Zhang Fubo, Li Junfeng. SARS-CoV-2 infection combined with Listeria meningitis: A case report and literature review[J]. Clinical Focus, 2024, 39(4): 347-351.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2024.04.009

https://huicui.hebmu.edu.cn/EN/Y2024/V39/I4/347

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References 22

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项目	入院第5 d	入院第12 d	入院第32 d
压力(mmH₂O)	85	50	135
颜色	黄色	淡粉色	无色
透明度	微混	浑浊	透明
凝块	无	无	无
新鲜红细胞百分比	90%	90%	0
小淋巴细胞百分比	84%	72%	95%
大淋巴细胞百分比	0	0	0
一般单核细胞百分比	1%	2%	3%
激活单核细胞百分比	0	0	0
中性粒细胞百分比	4%	5%	0
其他细胞百分比	异形淋巴细胞11%	异形淋巴细胞16%,浆细胞5%	浆细胞2%
白细胞计数(个/mm³)	865	513	30
红细胞计数(个/mm³)	50	18 000	5
氯化物(mmol/L)	109.80	106.20	118.90
乳酸脱氢酶(U/L)	585.60	181.10	72.40
脑脊液蛋白(mg/dl)	683.30	758.60	136.60
葡萄糖(mmol/L)	3.81	5.70	2.98
腺苷脱氨酶(U/L)	33.50	21.10	4.00
墨汁染色	-	/	-
革兰染色	未查见细菌	/	未查见细菌
抗酸染色	未发现抗酸杆菌	/	未发现抗酸杆菌
其他	-	/	-
免疫球蛋白G(mg/dl)	79.3	132.0	24.5
细菌培养	LM	无细菌生长	无细菌生长
新型隐球菌荚膜抗原	-	/	-
基因检测(宏基因二代测序)	LM	未查见细菌	LM,巨细胞病毒,EB病毒

项目	入院第5 d	入院第12 d	入院第32 d
压力(mmH₂O)	85	50	135
颜色	黄色	淡粉色	无色
透明度	微混	浑浊	透明
凝块	无	无	无
新鲜红细胞百分比	90%	90%	0
小淋巴细胞百分比	84%	72%	95%
大淋巴细胞百分比	0	0	0
一般单核细胞百分比	1%	2%	3%
激活单核细胞百分比	0	0	0
中性粒细胞百分比	4%	5%	0
其他细胞百分比	异形淋巴细胞11%	异形淋巴细胞16%,浆细胞5%	浆细胞2%
白细胞计数(个/mm³)	865	513	30
红细胞计数(个/mm³)	50	18 000	5
氯化物(mmol/L)	109.80	106.20	118.90
乳酸脱氢酶(U/L)	585.60	181.10	72.40
脑脊液蛋白(mg/dl)	683.30	758.60	136.60
葡萄糖(mmol/L)	3.81	5.70	2.98
腺苷脱氨酶(U/L)	33.50	21.10	4.00
墨汁染色	-	/	-
革兰染色	未查见细菌	/	未查见细菌
抗酸染色	未发现抗酸杆菌	/	未发现抗酸杆菌
其他	-	/	-
免疫球蛋白G(mg/dl)	79.3	132.0	24.5
细菌培养	LM	无细菌生长	无细菌生长
新型隐球菌荚膜抗原	-	/	-
基因检测(宏基因二代测序)	LM	未查见细菌	LM,巨细胞病毒,EB病毒