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Predictive value of musculoskeletal ultrasonography in clinical remission of  disease recurrence in patients with rheumatoid arthritis

  

  1. 1.Department of Rheumatology and Immunology, Shunyi District Hospital, Beijing 101300, China;
    2.Department of Rheumatology and Immunology, First Hospital of Peking University, Beijing 100034, China
  • Online:2019-09-20 Published:2019-11-19
  • Contact: Corresponding author: Zhao Xuegang, Email:zhaoxg101300@163.com

Abstract: Objective  To investigate the relapses of rheumatoid arthritis(RA) and the correlation with musculoskeletal ultrasound.Methods  A total of 63 RA patients whose erythrocyte sedimentation rate(DAS28ESR) were continuously ≤2.6  were followed up strictly for at least 3 months. The clinical data and ultrasound results of 28 articular musculoskeletal specimens were recorded.With the persistence of the original treatment, patients' 3month clinical information were collected.Patients with disease recurrence (DAS28ESR) were divided into the disease recurrence group, patients with disease continuous remission (DAS28ESR≤2.6)  were divided into the continuous remission group. The differences of clinical indexes and ultrasonography images between disease recurrence group and continuous remission group were compared  by logistic regression analysis. Results  A total of 26 cases with  disease  recurrence (41.3%)  and 37 cases with  continuous remission(58.7%) were observed within 3 months. Detection rate of subclinical synovitis of   disease recurrence group was obviously higher than that of  continuous  remission group,while it  was lower in depth remission rate(DAS28ESR<1.6). Subclinical synovitis was an independent risk factor for the recurrence of RA, while  the deep remission was a protective factor for the recurrence of RA. Conclusion  The recurrence of RA was related to high disease activity and subclinical synovitis.

Key words: arthritis, , rheumatoid, recurrence, musculoskeletal ultrasonography, clinical remission