Abstract: Objective  To investigate the predictivevalue of plasma neutrophilto lymphocyte ratio (NLR), plateletto lymphocyte ratio (PLR) in the prognosis of intravenous thrombolysis in patients with cerebral infarction within 24 hours. Methods  Totally 128 patients who received intravenous thrombolysis for cerebral infarction were continuously included.According to the modified Rankin scale (mRS) score after 90 days of thrombolytic therapy,  all patients were separated into good prognosis group (mRS 02 points,  75 cases) and poor prognosis group (mRS 36 points,  53 cases). General information of patients were collectedin order to measure the blood routine,  blood uric acid,  homocysteine,  blood lipidand calculate NLR and PLR after thrombolysis. Following the binary logistic regression analysis, the receiver operating characteristic curve (ROC) was used to further evaluate the predictive value for the prognosis of thrombolysis in patients with cerebral infarction. Results  There were statistically significant difference in NLR and PLR between two groups (P<0.01). Further analysis of NLR, PLR,  and their combined indicators by using ROC found that the area under the curve (AUC) for judging the prognosis of thrombolytic therapy in cerebral infarction was 0.772. When the optimal threshold was 3.755,  the sensitivity was 69.8% and the specificity was 74.7%. And the AUC measured by the detection of PLR was 0.746. When the optimal threshold  was 145.055,  the sensitivity was 64.2% and the specificity was 78.7%. The AUC measured by the combined detection of NLR and PLR was 0.781. When the critical value was 1.337,  the sensitivity was 69.8%  and the specificity was 76.5%.Conclusion  The NLR,  PLR and their combined indicators are new indicators of inflammation,  and their elevation has good predictive value for the poor prognosis of thrombolysis in patients with cerebral infarction.

Key words: cerebral infarction, thrombolysis, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio