Abstract: Objective  To investigate the status and influencing factors of antiplatelet drug compliancein patients with ischemic stroke.Methods  A total of 739 patients with ischemic stroke were consecutively selected. The general clinical data and related risk factors of those patients were recorded, then they were followed up at three, six and twelve months after discharge in order to see the conditions of drug usageand the reasons of withdrawal (or dose reduction) of antiplatelet drug. Results  The number and proportion of patients taking antiplatelet drugs at thee, six and twelve months were 677(91.61%), 635(85.93%) and 608(82.28%),  respectively.  Hypertension was the independent factor associated with antiplatelet drug compliance (OR=1.787, 95%CI=1.133, 2.817, P<0.05). And the withdrawal after the improvement of disease on one's own (20.61%) was the main reason for poor compliance.Conclusion  Antiplatelet medication compliance in patients with ischemic stroke decreases gradually as discharge timegoes on. Patients with hypertension have better compliance with antiplatelet drugs. The main reason for poor complianceis that patients stopped taking drugs by themselves after getting better.

Key words: cerebrovascular accident, platelet aggregation inhibitors, patient compliance, hypertension