Abstract: Objective  To observe the serum levels of visceral adipose tissuederived serine protease inhibitor (Vaspin) in patients with unstable angina (UA) and to explore the correlation between serum Vaspin and soluble vascular cell adhesion molecule1 (sVCAM1),  soluble intercellular cell adhesion molecule1 (sICAM1). Methods  Quantitative sandwich enzymelinked immunoassay technology was used to detect the changes of serum Vaspin,  sVCAM1 and sICAM1 levels in 90 patients with UA(UA group),  90 patients with stable angina (SA group) and 80 healthy subjects (control group). Other clinical biochemical indicators were routinely detected at the same time. In UA group,  the relationships between serum Vaspin and sVCAM1,  sICAM1,  highsensitivity Creactive protein (hsCRP) and other biochemical indicators were analyzed by Pearson correlation analysis. Results  The levels of serum sVCAM1 and sICAM1 in  UA group were significantly higher than those in SA group（respectively P＜0.01）  and  control group（respectively P＜0.01）. Serum Vaspin levels in  UA group were significantly negatively correlated with sVCAM1 (r＝0.354，P=0.001),  sICAM1 (r＝0.287，P=0.006), and hsCRP (r＝0.3111，P=0.003) levels. Conclusion  The levels of serum Vaspin in patients with UA are significantly decreased,  and are negatively correlated with sVCAM1,  sICAM1 and hsCRP,  suggesting that serum Vaspin is closely related to vascular endothelial damage and the severity of coronary artery disease,  and may be important biomarkers of  UA  in patients.

Key words: angina, unstable, cytokines, cell adhesion molecules, endothelium, vascular