Role of serum MMP-1,  MMP-3,  TIMP-1 and Hcy levels in patients with hypertension complicated with atrial fibrillation

doi:10.3969/j.issn.1004-583X.2020.11.003

Abstract

Abstract: Objective To explore the role of serum matrix metalloproteinase (MMP) 1, MMP 3, matrix metalloproteinase inhibitor 1 (TIMP1) and homocysteine (Hcy) levels in patients with hypertension complicated with atrial fibrillation (AF).Methods A total of 161 patients with hypertension who had not been treated or discontinued from medication for more than one week were divided into sinus rhythm group and atrial fibrillation group according to ECG, dynamic ECG and medical history. Serum MMP1, MMP3, TIMP1, Hcy, uric acid (UA) and lipid levels were detected in all patients, and left atrial diameter (LAD) was determined by echocardiography. Results Compared with sinus rhythm group, the age, UA, Hcy, MMP1/TIMP1, MMP3/TIMP1 and LAD of atrial fibrillation group were all increased(P<0.05), while the total cholesterol (TC) and lowdensity lipoprotein cholesterol (LDLC) were significantly reduced(P<0.05). Age, Hcy, LAD and MMP1/TIMP1 were independent risk factors for atrial fibrillation in patients with hypertension. Conclusion Old age, high Hcy, enlarged LAD and increased MMP1/TIMP1 are independent risk factors for atrial fibrillation in patients with hypertension.

Key words: atrial fibrillation, matrix metalloproteinases, cysteine

CLC Number:

R541.75

Lu Yuqin, Li Yingdong, Liu Kai. Role of serum MMP-1, MMP-3, TIMP-1 and Hcy levels in patients with hypertension complicated with atrial fibrillation[J]. Clinical Focus, 2020, 35(11): 976-979.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2020.11.003

https://huicui.hebmu.edu.cn/EN/Y2020/V35/I11/976

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Role of serum MMP-1, MMP-3, TIMP-1 and Hcy levels in patients with hypertension complicated with atrial fibrillation

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