High-flux hemodialysis in the frailty of elderly patients with end-stage renal disease

doi:10.3969/j.issn.1004-583X.2021.04.007

Abstract

Abstract:

Objective To analyze the effects of high-flux hemodialysis(HFHD) and low-flux hemodialysis(LFHD) on the frailty of elderly patients with end-stage renal disease(ESRD). Methods The study involved 86 patients with ESRD over 60 years who were treated from Nov 2018 to May 2019. The debilitating condition of the patients were assessed before dialysis, the patients were divided into LFHD group and HFHD group according to odd and even ways, 43 cases in each group; and the general information and auxiliary examination results between the two groups before and after treatment were collected to compare the difference in the incidence of frailty and influencing factors. Results The incidence of frailty(P<0.05), blood phosphorus(P), parathyroid hormone(PTH), β₂-microglobulin(β₂-MG), vitamin B₁₂(VitB₁₂), triglyceride(TG), creatinine(SCr),urea (Urea) and albumin(ALB) in HFHD group were significantly decreased than those in LFHD group(P<0.05), while hemoglobin(Hb), high-density lipoprotein(HDL-C) and hematocrit(HCT) in HFHD group significantly increased than those in LFHD group (P<0.05). Logistic regression analysis showed that age, P, PTH, β₂-MG, Hb, ALB were the common influencing factors of frailty in both groups(P<0.05). Conclusion HFHD can improve the frailty of elderly ESRD patients.

Key words: frailty, high flux hemodialysis, factors analysis, statistics, elderly

CLC Number:

R692.5

Zhang Jinjin, Jin Ruixia, Sun Wei. High-flux hemodialysis in the frailty of elderly patients with end-stage renal disease[J]. Clinical Focus, 2021, 36(4): 328-331.

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URL: https://huicui.hebmu.edu.cn/EN/10.3969/j.issn.1004-583X.2021.04.007

https://huicui.hebmu.edu.cn/EN/Y2021/V36/I4/328

Figures/Tables 7

References 13

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组别	例数	K(mmol/L)		Na(mmol/L)		Ca(mmol/L)		P(mmol/L)
组别	例数	治疗前	透析后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
HFHD	43	4.26±0.69	3.77±0.80^*	138.49±4.59	140.37±4.78	2.10±0.18	2.08±0.09	2.15±0.40	1.89±0.33^*
LFHD	43	4.40±0.80	3.71±0.41^*	139.16±3.44	138.16±3.07	2.13±0.13	2.09±0.17	2.12±0.44	2.20±0.51^*
t值		-0.888	0.267	-0.771	-1.698	-0.942	-3.730	0.350	-3.002
P值		0.377	0.791	0.443	0.089	0.346	0.710	0.727	0.003

组别	例数	K(mmol/L)		Na(mmol/L)		Ca(mmol/L)		P(mmol/L)
组别	例数	治疗前	透析后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
HFHD	43	4.26±0.69	3.77±0.80^*	138.49±4.59	140.37±4.78	2.10±0.18	2.08±0.09	2.15±0.40	1.89±0.33^*
LFHD	43	4.40±0.80	3.71±0.41^*	139.16±3.44	138.16±3.07	2.13±0.13	2.09±0.17	2.12±0.44	2.20±0.51^*
t值		-0.888	0.267	-0.771	-1.698	-0.942	-3.730	0.350	-3.002
P值		0.377	0.791	0.443	0.089	0.346	0.710	0.727	0.003

组别	例数	Urea(mmol/L)		SCr(mmol/L)		UA(mmol/L)		VitB₁₂ (pmol/L)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
HFHD	43	26.86±8.53	23.62±4.65^*	862.77±264.91	647.33±88.54^*	441.47±152.55	335.16±130.64^*	404.48±146.47	268.49±112.37^*
LFHD	43	26.81±4.14	25.45±3.30^*	822.88±157.41	709.60±120.81^*	433.79±98.52	342.07±117.31^*	421.44±59.36	458.93±123.09
t值		-0.082	2.155	-0.268	2.675	-0.086	-0.258	0.679	-7.921
P值		0.935	0.037	0.789	0.011	0.931	0.797	0.499	0.000

组别	例数	Urea(mmol/L)		SCr(mmol/L)		UA(mmol/L)		VitB₁₂ (pmol/L)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
HFHD	43	26.86±8.53	23.62±4.65^*	862.77±264.91	647.33±88.54^*	441.47±152.55	335.16±130.64^*	404.48±146.47	268.49±112.37^*
LFHD	43	26.81±4.14	25.45±3.30^*	822.88±157.41	709.60±120.81^*	433.79±98.52	342.07±117.31^*	421.44±59.36	458.93±123.09
t值		-0.082	2.155	-0.268	2.675	-0.086	-0.258	0.679	-7.921
P值		0.935	0.037	0.789	0.011	0.931	0.797	0.499	0.000

组别	例数	PTH(pg/ml)		β₂-MG (mg/L)			RBC(×10¹²/L)		WBC(×10⁹/L)
组别	例数	治疗前	治疗后	治疗前	治疗后		治疗前	治疗后	治疗前	治疗后
HFHD	43	404.48±146.47	268.49±112.37^*	31.67±8.75		19.71±5.04^*	7.10±2.51	7.22±2.31^*	7.10±2.51	7.22±2.31
LFHD	43	421.44±59.36	458.93±123.09^*	32.76±6.33		34.85±5.87	7.18±2.37	7.31±1.70	7.18±2.37	7.31±1.70
t值		-1.339	7.493	-0.664		12.832	-0.174	1.398	-0.142	-0.212
P值		0.181	0.000	0.509		0.000	0.862	0.166	0.888	0.832