丹参多酚酸盐对不稳定型心绞痛患者血清超敏C反应蛋白及肿瘤坏死因子α水平的影响

doi:10.3969/j.issn.1004-583X.2016.02.013

临床荟萃 ›› 2016, Vol. 31 ›› Issue (2): 191-193.doi: 10.3969/j.issn.1004-583X.2016.02.013

丹参多酚酸盐对不稳定型心绞痛患者血清超敏C反应蛋白及肿瘤坏死因子α水平的影响

毛艳阳¹,王军强²,王晨霞¹,王聪霞³

1.延安大学附属医院东关心脑血管病专科医院心二科,陕西延安 716000;
2.延安大学附属医院口腔修复科,陕西延安 716000;
3.西安交通大学第二附属医院心内科,陕西延安 710004

收稿日期:2015-10-12 出版日期:2016-02-05 发布日期:2016-04-18
通讯作者: 王聪霞,Email:zmy89566@163.com
基金资助:
国家自然科学基金资助项目(81273878)

Effect of salvianolate on serum levels of hs-CRP and TNF-α in unstable angina patients

Mao Yanyang¹,Wang Junqiang²,Wang Chenxia¹,Wang Congxia³

1.Second Department of Cardiology,Yan'an University Affiliated Hospital,Yan'an 716000,China;
2.Department of Oral Repair, Yan'an University Hospital, Yan'an 716000,China;
3.Department of Cardiology, the Second Affiliated Hospital of Xi'an Jiaotong University, Yan'an 710004,China

Received:2015-10-12 Online:2016-02-05 Published:2016-04-18
Contact: Wang Congxia,Email:zmy89566@163.com

摘要/Abstract

摘要： 目的探讨丹参多酚酸盐(salvianolate, SV)对不稳定型心绞痛(unstable angina, UA)患者超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)水平的影响。方法 UA患者96例随机分为两组,观察组和对照组各48例,对照组给予单纯西医治疗,观察组在对照组基础上联用SV进行治疗,治疗2周。治疗前后监测两组hs-CRP、TNF-α水平,并对综合疗效进行评价。结果治疗前,两组hs-CRP、TNF-α水平差异无统计学意义(P＞0.05);治疗1周和2周后,观察组hs-CRP水平分别为(12.5±2.2) mg/L和(5.2±1.1) mg/L,对照组为(15.3±2.8) mg/L和(8.5±1.5) mg/L,观察组明显低于对照组(P＜0.05);治疗1周和2周后,观察组TNF-α水平与对照组相比明显更低(P＜0.05);观察组有效率为93.8%(45/48),对照组为77.1%(37/48),观察组有效率明显高于对照组(P＜0.05)。结论 SV联合治疗UA能通过有效降低患者的hs-CRP、TNF-α水平改变炎症反应程度,从而改善UA患者的临床症状,值得在临床上进一步推广。

关键词: 心绞痛, 不稳定型, C反应蛋白质, 肿瘤坏死因子α, 丹参多酚酸盐

Abstract: Objective To observe the effect of salvianolate on plasma high-sensitivity C-reactive protein(hs-CRP) and tumor necrosis factor( TNF-α) in unstable angina(UA) patients.Methods Ninety-six UA patients were divided into two groups. Control group of 48 cases received conventional western medicine treatment,48 cases in the treatment group received salvianolate on the basis of control group treatment. Two weeks was as a period of treatment. The therapeutic effect was evaluated after two courses. The level of hs-CRP and TNF-α in two groups were detected before and 1 week,2 weeks after treatment.Results Before treatment,hs-CRP and TNF-α levels between two groups had no statistically significant (P>0.05). After treatment for 1 week and 2 weeks hs-CRP in observation group was (12.5±2.2) mg/L and (5.2±1.1) mg/L respectively, while that in the control group was (15.3±2.8) mg/L and (8.5±1.5) mg/L. There was the significant difference between two group (P<0.05); Moreover, TNF-α in observation group was significantly lower than that in control group (P<0.05). The efficacy in observation group was 93.8% (45/48), that in control group was 77.1% (37/48).The observation group was significantly higher than the control group (P<0.05).Conclusion Salvianolate combined treatment might improve the clinical symptoms of UA patients by decreasing hs-CRP and TNF-α.

Key words: angina, unstable, C-reactive protein, tumor necrosis factor-alpha, salvia miltiorrhiza

中图分类号:

R541.4

毛艳阳,王军强,王晨霞,王聪霞. 丹参多酚酸盐对不稳定型心绞痛患者血清超敏C反应蛋白及肿瘤坏死因子α水平的影响[J]. 临床荟萃, 2016, 31(2): 191-193.

Mao Yanyang,Wang Junqiang,Wang Chenxia,Wang Congxia. Effect of salvianolate on serum levels of hs-CRP and TNF-α in unstable angina patients[J]. Clinical Focus, 2016, 31(2): 191-193.

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https://huicui.hebmu.edu.cn/CN/Y2016/V31/I2/191

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丹参多酚酸盐对不稳定型心绞痛患者血清超敏C反应蛋白及肿瘤坏死因子α水平的影响

Effect of salvianolate on serum levels of hs-CRP and TNF-α in unstable angina patients

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