老年脑梗死认知障碍与尿酸相关性研究

doi:10.3969/j.issn.1004-583X.2016.05.016

临床荟萃

老年脑梗死认知障碍与尿酸相关性研究

1.遂宁市中心医院神经内科,四川遂宁 629000; 2.泸州医学院附属医院神经内科,四川泸州 646000

出版日期:2016-05-05 发布日期:2016-05-04
通讯作者: 谭华,Email:182439789@qq.com

Relationship between uric acid and cognitive impairment in elderly patients with cerebral infarction

1. Department of Neurology, Suining Central Hospital, Suining 629000, China;
2. Department of Neurology, the Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China

Online:2016-05-05 Published:2016-05-04
Contact: Corresponding author：Tan Hua，Email：182439789@qq.com

摘要/Abstract

摘要： 目的探讨老年脑梗死患者认知障碍的发生率及其与血尿酸的相关性。方法连续收集神经内科老年
脑梗死患者102例,根据中文版蒙特利尔认知量表(MoCA)评分分为认知障碍组及非认知障碍组,比较两组尿酸水平
及相关因素差异,应用Logistic回归分析评估尿酸与认知障碍的相关性。结果老年脑梗死认知障碍发生率为
58.8%(60/102)。认知障碍组血尿酸明显高于非认知障碍组(P <0.01)。多因素Logistic回归显示校正教育年限、
高血压后,高尿酸仍是老年脑梗死患者发生认知障碍的危险因素(OR =1.043,95%CI =1.020~1.067,P <0.01)。
结论老年脑梗死患者急性期具有较高的认知障碍发生率,尿酸是老年脑梗死认知障碍的危险因素。

关键词: 脑梗死, 认知障碍, 尿酸

Abstract:

Objective To investigate the incidence of cognitive impairment and its correlation with uric acid in elderly patients with cerebral infarction. Methods A total of 102 elderly patients with cerebral infarction were selected in clinical practice. Based on the MoCA, all patients were divided into two groups: cognitive impairment group and normal cognitive group. Differences in the uric acid and other related factors were compared between two groups, and logistic regression analysis was used to estimate the correlation between uric acid and cognitive impairment. Results The incidence of cognitive impairment among all 102 patients was 58.8% (60 cases). Serum uric acid was significantly higher in cognitive impairment group than in normal group (P＜0.01). The multiple logistic regression analysis showed that high uric acid was associated with cognitive impairment (OR=1.043, 95%CI 1.0201.067,P＜0.01). Conclusion The incidence of cognitive impairment in elderly patients with cerebral infarction was higher, and uric acid was considered the risk factor of cognitive impairment in elderly patients with cerebral infarction.

Key words: brain infarction, cognition disorders, uric acid

徐磊1,喻明1,谭华2. 老年脑梗死认知障碍与尿酸相关性研究[J]. 临床荟萃, doi: 10.3969/j.issn.1004-583X.2016.05.016.

Xu Lei1, Yu Ming1, Tan Hua2. Relationship between uric acid and cognitive impairment in elderly patients with cerebral infarction[J]. Clinical Focus, doi: 10.3969/j.issn.1004-583X.2016.05.016.

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链接本文: https://huicui.hebmu.edu.cn/CN/10.3969/j.issn.1004-583X.2016.05.016

https://huicui.hebmu.edu.cn/CN/Y2016/V31/I5/536

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老年脑梗死认知障碍与尿酸相关性研究

Relationship between uric acid and cognitive impairment in elderly patients with cerebral infarction

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