关键词: 真菌血症, 念珠菌病, 重症监护室 , 降钙素原, 葡聚糖

Abstract: ObjectiveTo study the clinical characteristics， prevention strategy and treatment of candidemia in critical patients. MethodsA retrospective analysis was made in the  clinical data of ICU for patients with candidemia. ResultsCandida was found in 23 blood strains culture from hospital acquired infected patients， including 11 cases(52.2%) of Candida albicans and 12 cases(47.8%) of non Candida albicans. In all 23 cases， broadspectrum antibiotics use were found in 18 cases， center venous catheterization in 16 cases， aged in 15 cases， abdominal surgery in 10 cases， prolonged ICU stay (> 7 days) in 19 cases， tracheal intubation in 13 cases， and elevated Acute Physiology and Chronic Health Evaluation (APACHE Ⅱ) ≥20 in 14 cases. The levels of serum procalcitonin(PCT) and 1， 3Dbetaglucan (G test) were (0.58±0.25) μg/L and (210.1±147.9)  ng/L.15 patients were treated by Caspofungin. The total mortality was 47.8%. ConclusionCandida albicans infection was the highest reason of candidemia in patients with multiple risk factors. For highrisk patients， more attention should be payed in the levels of serum PCT and G test， etiology examination and timely choice of antifungal drug to improve the prognosis.

Key words: fungemia, candidiasis, intensive care units, procalcitonin, glucans